Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Amplified in Breast Cancer 1

  • Jianming Xu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_248-3

Synonyms

Definition

AIB1 is a 160-kDa intracellular protein that enhances gene expression through interacting with nuclear hormone receptors and some other transcription factors and serving as a transcriptional coactivator. The AIB1 gene is amplified and overexpressed in some human breast tumors.

Characteristics

Molecular Structure and Functional Domains

The human AIB1 gene is located in chromosome 20, and it encodes for a 160-kDa intracellular protein with 1402 amino acid residues. AIB1 is a member of the p160 steroid receptor coactivator (SRC) family that also includes SRC-1 and the transcriptional intermediary factor 2 (TIF2). AIB1 contains multiple structural and functional domains (Fig. 1). The N-terminal basic helix-loop-helix/Per-Ah receptor...

Keywords

Mammary Gland Tumor Arginine Methyltransferase Mammary Gland Epithelial Cell Mammary Gland Tumorigenesis AIB1 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Anzick SL et al (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277:965–968CrossRefPubMedGoogle Scholar
  2. Kuang SQ et al (2004) AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res 64:1875–1885CrossRefPubMedGoogle Scholar
  3. Torres-Arzayus MI et al (2004) High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell 6:263–274CrossRefPubMedGoogle Scholar
  4. Xu J, Li Q (2003) Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol 17:1681–1692CrossRefPubMedGoogle Scholar
  5. Xu J et al (2000) The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci USA 97:6379–6384CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonUSA