Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Amplified in Breast Cancer 1

  • Jianming Xu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_248-3



AIB1 is a 160-kDa intracellular protein that enhances gene expression through interacting with nuclear hormone receptors and some other transcription factors and serving as a transcriptional coactivator. The AIB1 gene is amplified and overexpressed in some human breast tumors.


Molecular Structure and Functional Domains

The human AIB1 gene is located in chromosome 20, and it encodes for a 160-kDa intracellular protein with 1402 amino acid residues. AIB1 is a member of the p160 steroid receptor coactivator (SRC) family that also includes SRC-1 and the transcriptional intermediary factor 2 (TIF2). AIB1 contains multiple structural and functional domains (Fig. 1). The N-terminal basic helix-loop-helix/Per-Ah receptor...


Mammary Gland Tumor Arginine Methyltransferase Mammary Gland Epithelial Cell Mammary Gland Tumorigenesis AIB1 Gene 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonUSA