Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Gonadotropin-Releasing Hormone

  • Zvi Naor
  • Rony Seger
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2477-2



GnRH is the central regulator of reproduction. GnRH binds and activates its cognate receptor in pituitary gonadotropes, resulting in the synthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) that control ovulation and spermatogenesis.


To isolate GnRH, Andrew Schally’s group collected 2.5 million pig brains, while Roger Guillemin’s group collected 5 million sheep brains, and while competing, both groups have announced in 1971 the isolation and structure of GnRH as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2. For their outstanding work, both Guillemin and Schally received the Nobel Prize for Medicine in 1977.

The pulsatile nature of hypothalamic GnRH secretion is absolutely required for physiological maintenance of gonadotropin (LH and FSH) secretion. Continuous exposure of the pituitary to GnRH results in...


Prostate Cancer Luteinizing Hormone Follicle Stimulate Hormone GnRH Agonist GnRH Antagonist 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology, The George S. Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael
  2. 2.Department of Biological RegulationThe Weizmann Institute of ScienceRehovotIsrael