Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Gonadotropin-Releasing Hormone

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2477-2

Synonyms

Definition

GnRH is the central regulator of reproduction. GnRH binds and activates its cognate receptor in pituitary gonadotropes, resulting in the synthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) that control ovulation and spermatogenesis.

Characteristics

To isolate GnRH, Andrew Schally’s group collected 2.5 million pig brains, while Roger Guillemin’s group collected 5 million sheep brains, and while competing, both groups have announced in 1971 the isolation and structure of GnRH as pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2. For their outstanding work, both Guillemin and Schally received the Nobel Prize for Medicine in 1977.

The pulsatile nature of hypothalamic GnRH secretion is absolutely required for physiological maintenance of gonadotropin (LH and FSH) secretion. Continuous exposure of the pituitary to GnRH results in...

Keywords

Prostate Cancer Luteinizing Hormone Follicle Stimulate Hormone GnRH Agonist GnRH Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Burgus R, Butcher M, Ling N et al (1971) Molecular structure of the hypothalamic factor (LRF) of ovine origin monitoring the secretion of pituitary gonadotropic hormone of luteinization (LH). C R Acad Sci Hebd Seances Acad Sci D 273:1611–1613PubMedGoogle Scholar
  2. Kraus S, Naor Z, Seger R (2006) Gonadotropin-releasing hormone in apoptosis of prostate cancer cells. Cancer Lett 234:109–123CrossRefPubMedGoogle Scholar
  3. Reinhart J, Mertz LM, Catt KJ (1992) Molecular cloning and expression of cDNA encoding the murine gonadotropin-releasing hormone receptor. J Biol Chem 267:21281–21284PubMedGoogle Scholar
  4. Schally AV, Arimura A, Baba Y et al (1971) Isolation and properties of the FSH and LH-releasing hormone. Biochem Biophys Res Commun 43:393–399CrossRefPubMedGoogle Scholar
  5. Tsutsumi M, Zhou W, Millar RP et al (1992) Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol 6:1163–1169PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology, The George S. Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael
  2. 2.Department of Biological RegulationThe Weizmann Institute of ScienceRehovotIsrael