Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Glycobiology and Cancer

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2444-2

Definition

Glycobiology is a discipline of natural sciences covering studies of the structure, biosynthesis, and biology of glycans and glycoconjugates and proteins that specifically interact with these. It is involved in almost every aspect of cancer: transformation, progression, metastasis, diagnosis, monitoring, and therapy. Still, the general awareness of the potential and clinical use of discoveries in glycobiology among oncologists, or in oncology among glycobiologists, is limited.

Characteristics

Glycan Structural Diversity Is Theoretically Immense but Genetically Restricted

The field of glycobiology has evolved from mainly structural characterization of naturally occurring carbohydrates (sugars or glycans) to functional studies of the biology and interaction of such compounds with both endogenous and exogenous proteins, lectins typically equipped with carbohydrate recognizing domains (CRD). The glycans (Fig. 1) may occur as free oligosaccharides but are usually covalently...

Keywords

Glycan Structure Enzymatic Glycosylation Aberrant Glycosylation Homing Process Aglycone Part 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Chemistry and Transfusion Medicin, Institute of BiomedicineSahlgrenska academy at Göteborg UniversityGöteborgSweden