GSTs refer to a family of Phase 2 detoxification enzymes that catalyze the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds, thereby decreasing their reactivity with cellular macromolecules. This detoxification ability plays a pivotal role in cellular protection from oxidative stresses.
GSTs are divided into three distinct superfamilies: cytosolic, mitochondrial, and membrane-bound microsomal. Microsomal GSTs play a key role in the endogenous metabolism of leukotrienes and prostaglandins. The mammalian cytosolic GSTs are highly polymorphic and could be divided into six classes: alpha (A), mu (M), omega (O), theta (T), sigma (S), and pi (P). Classification is based on sharing greater than 60% identity within a class and focuses mainly on the more highly conserved N-terminal domain that contains a catalytically active tyrosine, cysteine, or serine...
KeywordsArsenic Trioxide Ethacrynic Acid Matched Normal Tissue GSTT1 Gene Reduce Survival Rate
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