Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Glutathione S-Transferase

  • Zhimin Yin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2441-2



GSTs refer to a family of Phase 2 detoxification enzymes that catalyze the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds, thereby decreasing their reactivity with cellular macromolecules. This detoxification ability plays a pivotal role in cellular protection from oxidative stresses.


GSTs are divided into three distinct superfamilies: cytosolic, mitochondrial, and membrane-bound microsomal. Microsomal GSTs play a key role in the endogenous metabolism of leukotrienes and prostaglandins. The mammalian cytosolic GSTs are highly polymorphic and could be divided into six classes: alpha (A), mu (M), omega (O), theta (T), sigma (S), and pi (P). Classification is based on sharing greater than 60% identity within a class and focuses mainly on the more highly conserved N-terminal domain that contains a catalytically active tyrosine, cysteine, or serine...


Arsenic Trioxide Ethacrynic Acid Matched Normal Tissue GSTT1 Gene Reduce Survival Rate 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.College of Life ScienceNanjing Normal UniversityNanjingPeople’s Republic of China