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Glutathione Conjugate Transporter RLIP76

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  • First Online:
Encyclopedia of Cancer

  • 37 Accesses

Synonyms

Ral-interacting protein 76kDa; RLIP76

Definition

RLIP76 is a multifunctional protein important for utilizing the energy currency adenosine triphosphate (ATP) to transport various chemical materials outside the cell. Through this transport process, this transporter protein converge many cell signaling processes through the modulation of substrate levels or the contribution of protein–protein interactions to stimulate cell signaling. Overexpression of RLIP76 has been correlated to contribute to the phenomenon known as multidrug resistance. This protein is also known to have a clinical impact in addition to multidrug resistance toward inflammation, heat and oxidative stress, radiation, and a culmination of these stressors allowing it to contribute to general stress resistance.

Characteristics

Ral-interacting protein 76 kDa (RLIP76), a known Ral effector, is a 655 amino acid long protein capable of the ATP-dependent transport of glutathione conjugates (GS-E, adducts of...

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References

  • Awasthi S, Cheng J, Singhal SS et al (2000) Novel function of human RLIP76: ATP-dependent transport of glutathione-conjugates and doxorubicin. Biochemistry 39:9327–9334

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  • Awasthi S, Cheng J, Singhal SS et al (2001) Identity of RLIP76 with the ATP-dependent transporter for glutathione conjugates and doxorubicin in human tissues. In: Gupta SK (ed) Pharmacology and therapeutics. Narosa Publishing House, Chennai, pp 713–725

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  • Awasthi S, Sharma R, Singhal SS et al (2002) RLIP76, A novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab Dispos 30:1300–1310

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  • Nadkar A, Pungaliya C, Drake K et al (2006) Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol 2(5):753–777

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  • Sharma R, Singhal SS, Cheng J et al (2001) RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Arch Biochem Biophys 391:171–179

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA

    Kenneth Drake

  2. United States Longview Cancer Center, Longview, TX, USA

    Sanjay Awasthi

  3. City of Hope, Duarte, CA, USA

    Yogesh C. Awasthi

Authors
  1. Kenneth Drake
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  2. Sanjay Awasthi
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  3. Yogesh C. Awasthi
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Corresponding author

Correspondence to Kenneth Drake .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Drake, K., Awasthi, S., Awasthi, Y.C. (2015). Glutathione Conjugate Transporter RLIP76. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_2439-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_2439-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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