Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Glutathione Conjugate Transporter RLIP76

  • Kenneth Drake
  • Sanjay Awasthi
  • Yogesh C. Awasthi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2439-2

Synonyms

Definition

RLIP76 is a multifunctional protein important for utilizing the energy currency adenosine triphosphate (ATP) to transport various chemical materials outside the cell. Through this transport process, this transporter protein converge many cell signaling processes through the modulation of substrate levels or the contribution of protein–protein interactions to stimulate cell signaling. Overexpression of RLIP76 has been correlated to contribute to the phenomenon known as multidrug resistance. This protein is also known to have a clinical impact in addition to multidrug resistance toward inflammation, heat and oxidative stress, radiation, and a culmination of these stressors allowing it to contribute to general stress resistance.

Characteristics

Ral-interacting protein 76 kDa (RLIP76), a known Ral effector, is a 655 amino acid long protein capable of the ATP-dependent transport of glutathione conjugates (GS-E, adducts of...

Keywords

Vinca Alkaloid Glutathione Conjugate Radiation Toxicity Mild Heat Shock Stimulate ATPase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Awasthi S, Cheng J, Singhal SS et al (2000) Novel function of human RLIP76: ATP-dependent transport of glutathione-conjugates and doxorubicin. Biochemistry 39:9327–9334CrossRefPubMedGoogle Scholar
  2. Awasthi S, Cheng J, Singhal SS et al (2001) Identity of RLIP76 with the ATP-dependent transporter for glutathione conjugates and doxorubicin in human tissues. In: Gupta SK (ed) Pharmacology and therapeutics. Narosa Publishing House, Chennai, pp 713–725Google Scholar
  3. Awasthi S, Sharma R, Singhal SS et al (2002) RLIP76, A novel transporter catalyzing ATP-dependent efflux of xenobiotics. Drug Metab Dispos 30:1300–1310CrossRefPubMedGoogle Scholar
  4. Nadkar A, Pungaliya C, Drake K et al (2006) Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol 2(5):753–777CrossRefPubMedGoogle Scholar
  5. Sharma R, Singhal SS, Cheng J et al (2001) RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Arch Biochem Biophys 391:171–179CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Kenneth Drake
    • 1
  • Sanjay Awasthi
    • 2
  • Yogesh C. Awasthi
    • 3
  1. 1.Department of Chemistry and BiochemistryUniversity of Texas at ArlingtonArlingtonUSA
  2. 2.United States Longview Cancer CenterLongviewUSA
  3. 3.City of HopeDuarteUSA