Glutathione Conjugate Transporter RLIP76
RLIP76 is a multifunctional protein important for utilizing the energy currency adenosine triphosphate (ATP) to transport various chemical materials outside the cell. Through this transport process, this transporter protein converge many cell signaling processes through the modulation of substrate levels or the contribution of protein–protein interactions to stimulate cell signaling. Overexpression of RLIP76 has been correlated to contribute to the phenomenon known as multidrug resistance. This protein is also known to have a clinical impact in addition to multidrug resistance toward inflammation, heat and oxidative stress, radiation, and a culmination of these stressors allowing it to contribute to general stress resistance.
KeywordsVinca Alkaloid Glutathione Conjugate Radiation Toxicity Mild Heat Shock Stimulate ATPase Activity
- Awasthi S, Cheng J, Singhal SS et al (2001) Identity of RLIP76 with the ATP-dependent transporter for glutathione conjugates and doxorubicin in human tissues. In: Gupta SK (ed) Pharmacology and therapeutics. Narosa Publishing House, Chennai, pp 713–725Google Scholar