Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Giant Cell Tumor

  • Isabella W. Y. Mak
  • Shalini Singh
  • Michelle Ghert
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2406-8

Definition

Giant cell tumor is a benign aggressive bone tumor characterized by lytic bone destruction, pathologic fracture, and high recurrence rates. The tumor most often affects young adults and is currently treated with surgical management.

Characteristics

Epidemiology and Pathophysiology of Giant Cell Tumor

Giant cell tumor of bone (GCT) is a rare, aggressive, and highly osteolytic bone tumor that is characterized by local osteolysis, regional pain, and the predisposition to pathological fracture (Turcotte 2006). It generally occurs in adults between the ages of 20 and 40 years (Niu et al. 2012). Giant cell tumor of the bone is very rarely seen in children or in adults older than 65 years of age. A male predominance exists, with a male-to-female ratio of 1.3–1.5:1 (Niu et al. 2012; Gupta et al. 2008).

Although benign, GCT of the bone shows a tendency for significant bone destruction, local recurrence, and occasionally metastasis (Takeuchi et al. 2011). It accounts for 3 % to 8 %...

Keywords

Stromal Cell Giant Cell Mesenchymal Stromal Cell Giant Cell Tumor Giant Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Her Majesty the Queen in Right of Canada 2012

Authors and Affiliations

  • Isabella W. Y. Mak
    • 1
  • Shalini Singh
    • 2
  • Michelle Ghert
    • 1
  1. 1.Department of Surgery, Hamilton Health SciencesJuravinski Cancer Centre, McMaster UniversityHamiltonCanada
  2. 2.Department of SurgeryMcMaster UniversityHamiltonCanada