Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Giant Cell Tumor

  • Isabella W. Y. Mak
  • Shalini Singh
  • Michelle Ghert
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2406-8


Giant cell tumor is a benign aggressive bone tumor characterized by lytic bone destruction, pathologic fracture, and high recurrence rates. The tumor most often affects young adults and is currently treated with surgical management.


Epidemiology and Pathophysiology of Giant Cell Tumor

Giant cell tumor of bone (GCT) is a rare, aggressive, and highly osteolytic bone tumor that is characterized by local osteolysis, regional pain, and the predisposition to pathological fracture (Turcotte 2006). It generally occurs in adults between the ages of 20 and 40 years (Niu et al. 2012). Giant cell tumor of the bone is very rarely seen in children or in adults older than 65 years of age. A male predominance exists, with a male-to-female ratio of 1.3–1.5:1 (Niu et al. 2012; Gupta et al. 2008).

Although benign, GCT of the bone shows a tendency for significant bone destruction, local recurrence, and occasionally metastasis (Takeuchi et al. 2011). It accounts for 3 % to 8 %...


Stromal Cell Giant Cell Mesenchymal Stromal Cell Giant Cell Tumor Giant Cell Tumor 
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  1. Atkins GJ, Haynes DR, Graves SE, Evdokiou A, Hay S et al (2000) Expression of osteoclast differentiation signals by stromal elements of giant cell tumors. J Bone Miner Res 15:640–649CrossRefPubMedGoogle Scholar
  2. Balke M, Campanacci L, Gebert C, Picci P, Gibbons M et al (2010) Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone. BMC Cancer 10:462CrossRefPubMedPubMedCentralGoogle Scholar
  3. Ghert M, Simunovic N, Cowan RW, Colterjohn N, Singh G (2007) Properties of the stromal cell in giant cell tumor of bone. Clin Orthop Relat Res 459:8–13CrossRefPubMedGoogle Scholar
  4. Gupta R, Seethalakshmi V, Jambhekar NA, Prabhudesai S, Merchant N et al (2008) Clinicopathologic profile of 470 giant cell tumors of bone from a cancer hospital in western India. Ann Diagn Pathol 12:239–248CrossRefPubMedGoogle Scholar
  5. Kremen TJ Jr, Bernthal NM, Eckardt MA, Eckardt JJ (2012) Giant cell tumor of bone: are we stratifying results appropriately? Clin Orthop Relat Res 470:677–683CrossRefPubMedPubMedCentralGoogle Scholar
  6. Lindeman JH, Hanemaaijer R, Mulder A, Dijkstra PD, Szuhai K et al (2004) Cathepsin K is the principal protease in giant cell tumor of bone. Am J Pathol 165:593–600CrossRefPubMedPubMedCentralGoogle Scholar
  7. Mak IW, Seidlitz EP, Cowan RW, Turcotte RE, Popovic S et al (2010) Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone. Hum Pathol 41:1320–1329CrossRefPubMedGoogle Scholar
  8. Mak IW, Cowan RW, Turcotte RE, Singh G, Ghert M (2011) PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis. PLoS One 6:e19975CrossRefPubMedPubMedCentralGoogle Scholar
  9. Niu X, Zhang Q, Hao L, Ding Y, Li Y et al (2012) Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution. J Bone Joint Surg Am 94:461–467CrossRefPubMedGoogle Scholar
  10. Singh S, Mak IW, Cowan RW, Turcotte R, Singh G et al (2011) The role of TWIST as a regulator in giant cell tumor of bone. J Cell Biochem 112:2287–2295CrossRefPubMedGoogle Scholar
  11. Takeuchi A, Tsuchiya H, Niu X, Ueda T, Jeon DG et al (2011) The prognostic factors of recurrent GCT: a cooperative study by the Eastern Asian Musculoskeletal Oncology Group. J Orthop Sci 16:196–202CrossRefPubMedGoogle Scholar
  12. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A et al (2010) Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol 11:275–280CrossRefPubMedGoogle Scholar
  13. Turcotte RE (2006) Giant cell tumor of bone. Orthop Clin North Am 37:35–51CrossRefPubMedGoogle Scholar
  14. Werner M (2006) Giant cell tumour of bone: morphological, biological and histogenetical aspects. Int Orthop 30:484–489CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Her Majesty the Queen in Right of Canada 2012

Authors and Affiliations

  • Isabella W. Y. Mak
    • 1
  • Shalini Singh
    • 2
  • Michelle Ghert
    • 1
  1. 1.Department of Surgery, Hamilton Health SciencesJuravinski Cancer Centre, McMaster UniversityHamiltonCanada
  2. 2.Department of SurgeryMcMaster UniversityHamiltonCanada