Giant Cell Tumor
Giant cell tumor is a benign aggressive bone tumor characterized by lytic bone destruction, pathologic fracture, and high recurrence rates. The tumor most often affects young adults and is currently treated with surgical management.
Epidemiology and Pathophysiology of Giant Cell Tumor
Giant cell tumor of bone (GCT) is a rare, aggressive, and highly osteolytic bone tumor that is characterized by local osteolysis, regional pain, and the predisposition to pathological fracture (Turcotte 2006). It generally occurs in adults between the ages of 20 and 40 years (Niu et al. 2012). Giant cell tumor of the bone is very rarely seen in children or in adults older than 65 years of age. A male predominance exists, with a male-to-female ratio of 1.3–1.5:1 (Niu et al. 2012; Gupta et al. 2008).