Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Gastrin

  • Hong He
  • Arthur Shulkes
  • Graham S. Baldwin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2331-10

Definition

Gastrin is a gastrointestinal hormone that is released from G cells in the gastric antrum and the duodenum. Gastrin acts via the cholecystokinin-2 receptor (CCK2R) to stimulate gastric acid secretion and also has important roles in the proliferation of epithelial cells in the gastrointestinal tract. Release of gastrin is stimulated by food, predominantly protein, and inhibited by a low gastric pH. Gastrin peptides may also function as growth factors in the development of colorectal cancer (CRC).

Characteristics

In 1905 the British physiologist J. S. Edkins discovered a blood-borne factor that originated from the distal part of the stomach and stimulated gastric acid secretion. He named the factor gastrin and proposed that its mechanism of action was analogous to that of the pancreatic secretagogue secretin from the duodenum. In the 1930s the existence of gastrin was confirmed by the isolation of a gastric acid-stimulating peptide from antral mucosa by the Russian chemist...

Keywords

Parietal Cell Gastric Acid Secretion Chronic Atrophic Gastritis Gastrin Release Gastrin Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Aly A, Shulkes A, Baldwin GS (2004) Gastrins, cholecystokinins and gastrointestinal cancer. Biochim Biophys Acta 1704:1–10PubMedGoogle Scholar
  2. Dockray GJ, Varro A, Dimaline R, Wang T (2001) The gastrins: their production and biological activities. Annu Rev Physiol 63:119–139CrossRefPubMedGoogle Scholar
  3. Shulkes A, Baldwin GS (2012) Gastrin. In: Kastin AJ (ed) Handbook of biologically active peptides, 2nd edn. Elsevier, AmsterdamGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Surgery, Austin HealthThe University of MelbourneHeidelbergAustralia