Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Gastric Cancer

  • Celso A. Reis
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2329-2

Synonyms

Definition

Gastric cancer includes a variety of tumors that develop in the stomach. The vast majority of these tumors, more than 95 %, are from epithelial origin and are named as gastric carcinomas. There are also less frequent nonepithelial tumors in the stomach, including lymphomas, and mesenchymal tumors.

Characteristics

Carcinomas of the stomach are heterogeneous tumors from the morphologic standpoint. This heterogeneity is reflected in the histopathologic classifications of the tumors. The most common classifications are the Lauren classification and the World Health Organization (WHO) classification.

The Lauren classification recognizes two major types of gastric carcinomas, the “intestinal” and the “diffuse,” which display different clinicopathological characteristics and occur in different epidemiologic settings. Microscopically, the “intestinal”-type gastric carcinoma retains a glandular structure and cellular adhesion/polarity....

Keywords

Gastric Cancer Gastric Carcinoma Pylorus Infection Intestinal Metaplasia Gastric Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  4. Reis CA, David L, Correa P et al (1999) Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Res 59:1003–1007PubMedGoogle Scholar
  5. Uemura N, Okamoto S, Yamamoto S et al (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345(11):784–789CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute of Molecular Pathology and ImmunologyUniversity of PortoPortoPortugal