Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Jun FujitaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2323-2



Gankyrin (Gann ankyrin-repeat protein; “Gann” in Japanese means cancer) is a small 25kD 226-amino acid protein originally identified as the product of an oncogene commonly overexpressed in human hepatocellular carcinoma (HCC). Independently, it was purified as the p28 component of the 19S regulator (PA700 complex) of the 26S proteasome. The gene is localized on human chromosome Xq22.3 and produces at least nine transcript variants encoding nine distinct proteins. Gankyrin associates with cyclin-dependent kinase 4 (CDK4) to control the phosphorylation of the retinoblastoma protein pRB and with the E3 ubiquitin ligase MDM2 to control the ubiquitylation and degradation of p53 (and possibly pRB).


Gankyrin is a small cytoplasm–nucleus shuttling protein highly conserved throughout evolution (∼40 % identity to yeast Nas6p). Structurally, gankyrin consists of seven, not five or six as originally suggested by its amino acid sequence, ankyrin repeats...


Acute Lymphoblastic Leukemia Ankyrin Repeat Early HCCs Motif LxCxE PA700 Complex 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Molecular Biology, Graduate School of MedicineKyoto UniversityKyotoJapan