Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

GAGE Proteins

  • Henrik J. DitzelEmail author
  • Morten F. Gjerstorff
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2301-2

Synonyms

Definition

Belong to the cancer testis antigen (CTA) family and consist of highly homologous proteins (GAGE 1, GAGE2A-E, GAGE10, GAGE12B-J, and GAGE13).

Characteristics

GAGE proteins are encoded by tandem repeats on chromosome X (p11.2–p11.4 region). GAGE 1 is unique among the GAGE proteins because of an exclusive C-terminal encoded by an exon that is interrupted in the other GAGE genes. The remaining GAGE members are composed of five exons encoding 116–117 amino acids with 98 % identity, while GAGE1 consist of 138 amino acids. The molecular size of GAGE proteins is 26–29 kDa.

In contrast to other CTAs, the expression of which in adult normal tissues is restricted to germ cells of testis, GAGE is also expressed in a subset of oocytes of resting primordial follicles and in maturing oocytes of ovaries. In the testicular seminiferous tubule, GAGE expression is restricted to the spermatogonia and, to a lesser degree, the primary spermatocytes. GAGE gene transcripts...

Keywords

Thyroid Cancer Esophageal Carcinoma Primordial Follicle Gage Gene Gage Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Eynde B, Van den Peeters O, De Backer O et al (1995) A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J Exp Med 182(3):689–698CrossRefPubMedGoogle Scholar
  2. Gjerstorff MF, Johansen LE, Nielsen O et al (2006) Restriction of GAGE protein expression to subpopulations of cancer cells is independent of genotype and may limit the use of GAGE proteins as targets for cancer immunotherapy. Br J Cancer 94(12):1864–1873CrossRefPubMedPubMedCentralGoogle Scholar
  3. Simpson AJ, Caballero OL, Jungbluth A et al (2005) Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 5(8):615–625 (Review)CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Cancer and Inflammation ReserchInstitute fo Molecular Medicine, University of Southern DenmarkOdense CDenmark
  2. 2.Department of OncologyOdense University HospitalOdense CDenmark