Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fusion Genes

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2285-5

Synonyms

Definition

A hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or deregulate a gene transcription).

Characteristics

A wide variety of recurrent molecular alterations has been associated with cancer including polymorphisms, changes in gene copy number (amplifications and deletions), point mutations, epigenetic modifications, and gene fusions due to structural chromosomal rearrangements, such as translocations and less frequently inversions. As for these last ones, the genes located at the breakpoints of the rearrangement may be structurally changed with dramatic effects on their products. Molecularly, two events of structural aberrations can be generated: “promoter swapping” (the exchange of promoter control regions) or fusion gene.

In detail (Fig. 1a), “promoter swapping” occurs when the regulatory elements of a gene...

Keywords

Retinoic Acid Papillary Thyroid Carcinoma Fusion Gene Chronic Myelogenous Leukemia Chromosomal Rearrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Tumor Genomic Unit, Department of Experimental OncologyIstituto Nazionale TumoriMilanItaly