Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Furin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2283-3

Synonyms

Definition

Furin (EC 3.4.21.75) is a highly specialized proteinase that cleaves the unique sequence motifs in a variety of proteins. Normally, following furin cleavage, the target protein is activated, and therefore, it can exhibit its biological activity. Because furin has been discovered first, currently, it is the most studied enzyme of the proprotein convertase (PC) family of serine proteinases. Seven distinct proprotein convertases of this family (furin, PC2, PC1/PC3, PC4, PACE4, PC5/PC6, and PC7) have been identified in humans, some of which have isoforms generated as the result of alternative splicing. Structurally and functionally, furin resembles its evolutionary precursor: the prohormone-processing enzyme, kexin (EC 3.4.21.61), which is encoded by the KEX2 gene of yeast Saccharomyces cerevisiae. The polypeptide sequence of the furin catalytic domain is...

Keywords

Tumorigenic Phenotype Cleavage Site Sequence Multiple Basic Amino Acid Constitutive Secretory Pathway Endoproteolytic Processing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Surgery/Division of Urology, Institut de Pharmacologie, Faculté de Médecine et des sciences de la santéUniversité de SherbrookeSherbrookeCanada
  2. 2.Burnham Institute for Medical ResearchLa JollaUSA