Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Funnel Factors

  • Santiago Ramón y Cajal
  • Marta Sesé
  • Gemma Armengol
  • Trond Aasen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2282-3

Definition

A funnel factor is a molecule that canalizes multiple upstream oncogenic signals to converge and drive specific phenotypic features or cancer hallmarks. The activity of multiple overlapping oncogenic signaling pathways inexorably passes and is canalized through the same funnel factor. Regardless of the upstream signaling alterations, expression of funnel factors correlates with the degree of malignancy of the tumor and the most relevant clinical parameters, such as metastasis and survival. Therefore, they may reflect the molecular information and malignant potential for each tumor.

Characteristics

Background of Molecular Human Carcinogenesis

Funnel factors are signaling nodes that channel the malignant signals, which are transduced through multiple upstream pathways or cascades. Several of these pathways or cascades are redundant, that is, different pathways can trigger the same or a similar cellular effect through the same funnel factor. Conceptually, at least ten major...

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References

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See Also

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Santiago Ramón y Cajal
    • 1
  • Marta Sesé
    • 1
  • Gemma Armengol
    • 2
  • Trond Aasen
    • 1
  1. 1.Department of PathologyVall d’Hebron University HospitalBarcelonaSpain
  2. 2.Faculty Biosciences, U. Biological AnthropologyUniversitat Autonoma de BarcelonaBarcelonaSpain