Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Forkhead Box M1

  • Andrei L. Gartel
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2248-2

Synonyms

Definition

FoxM1 is a transcription factor of the Forkhead family. The Forkhead family consists of about 50 transcription factors that share a conserved 100 amino acid (Forkhead or winged-helix) DNA-binding domain, which is responsible for DNA binding via the consensus TAAACA site. The human FoxM1 gene contains ten exons, and it is expressed as three alternatively spliced variants (a, b, c). FoxM1 is generally expressed in dividing cells, and it is required for proper cell proliferation. Furthermore, FoxM1 is essential for the execution of mitosis, and it is overexpressed in most human cancers. FoxM1 may directly induce tumorigenesis because of its dominant role in cell proliferation. Therefore, FoxM1 is an attractive target for small molecule inhibition in cancer treatment.

Characteristics

FoxM1 expression correlates with the proliferative state of cells. It is expressed in all embryonic tissues and in proliferating cells of epithelial and...

Keywords

Basal Cell Carcinoma Intrahepatic Cholangiocarcinomas Estrogen Receptor Expression FoxM1 Expression Forkhead Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kalinichenko VV, Major ML, Wang X et al (2004) Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 18:830–850CrossRefPubMedPubMedCentralGoogle Scholar
  2. Laoukili J, Stahl M, Medema RH (2007) FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta 1775:92–102PubMedGoogle Scholar
  3. Radhakrishnan SK, Bhat UG, Hughes DE et al (2006) Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1. Cancer Res 66:9731–9735CrossRefPubMedGoogle Scholar
  4. Wang IC, Chen YJ, Hughes D et al (2005) Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol 25:10875–10894CrossRefPubMedPubMedCentralGoogle Scholar
  5. Wonsey DR, Follettie MT (2005) Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe. Cancer Res 65:5181–5189CrossRefPubMedGoogle Scholar

See Also

  1. (2012) CDC25. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 704. doi: 10.1007/978-3-642-16483-5_953Google Scholar
  2. (2012) CDK inhibitors. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 705. doi:10.1007/978-3-642-16483-5_963Google Scholar
  3. (2012) C-Myc. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 886. doi: 10.1007/978-3-642-16483-5_1232Google Scholar
  4. (2012) Gli. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1552. doi: 10.1007/978-3-642-16483-5_2418Google Scholar
  5. (2012) P19ARF. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2739. doi:10.1007/978-3-642-16483-5_4326Google Scholar
  6. (2012) Siomycin A. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3412. doi:10.1007/978-3-642-16483-5_5318Google Scholar
  7. (2012) Sonic hedgehog. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3471. doi: 10.1007/978-3-642-16483-5_5420Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Illinois at ChicagoChicagoUSA