Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Follicular Lymphoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2240-2

Synonyms

FL

Definition

A common low-grade B-cell lymphoma, which accounts for ca. 40% of B-cell lymphomas. Typically these lymphomas carry a translocation t(14;18), which brings the rearranged BCL-2 gene (chromosome 18) under the control of the immunoglobulin enhancer (chromosome 14). Tumors usually express B-cell markers and surface immunoglobulin. Many patients do not require treatment for a long time. A characteristic feature is a spontaneous “waxing and waning” of the enlarged lymph nodes, which may reflect residual but inefficient attempts of the immune system to eliminate the cancer. FL is not considered curable, except for patients in very early stages of disease. Often this lymphoma transforms into a more aggressive form of lymphoma, diffuse large B-cell lymphoma, which carries a poor prognosis.

Cross-References

Keywords

Lymph Node Immune System Cancer Research Poor Prognosis Characteristic Feature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

See Also

  1. (2012) Translocation t(14;18). In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3773. doi: 10.1007/978-3-642-16483-5_5946Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany