Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fluoxetine

  • Dan Peer
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2224-2

Synonyms

Definition

Fluoxetine hydrochloride is a drug used in the clinic for the treatment of depression and for a broad spectrum of psychiatric disorders. Fluoxetine has also been shown to inhibit multidrug resistance extrusion pumps expressed in a variety of cancer cells.

Characteristics

Fluoxetine hydrochloride is a drug used clinically in depression, and in a wide spectrum of psychiatric disorders. Fluoxetine was derived from an antihistamine (diphenhydramine) and found to inhibit reuptake of the neurotransmitter serotonin. Fluoxetine is also used (off-label) to treat many other conditions, including attention-deficit/hyperactivity disorder (ADHD). The mechanism by which the drug operates is still unclear. Fluoxetine has been shown to be effective in cancer therapy in two areas: as an anticancer effector inducing apoptosis, as reported in vitro for Burkitt lymphoma (a type of B cell lymphoma), glioma, and neuroblastomacells,...

Keywords

Cancer Stem Cell Chemotherapeutic Drug Drug Accumulation Multiple Drug Resistance Complete Depletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Levkovitz Y, Gil-Ad I, Zeldich E et al (2005) Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines. Evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci 27:29–42CrossRefPubMedGoogle Scholar
  2. Peer D, Margalit R (2006) Fluoxetine and reversal of multidrug resistance. Cancer Lett 237:180–187CrossRefPubMedGoogle Scholar
  3. Peer D, Dekel Y, Melikhov D et al (2004) Fluoxetine inhibits multidrug resistance extrusion pumps and enhances responses to chemotherapy in syngeneic and in human xenograft mouse tumor models. Cancer Res 64:7562–7569CrossRefPubMedGoogle Scholar
  4. Serafeim A, Holder MJ, Grafton G et al (2003) Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood 101:3212–3219CrossRefPubMedGoogle Scholar

See Also

  1. (2012) ABC (ATP-Binding Cassette) Superfamily. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 10. doi: 10.1007/978-3-642-16483-5_10Google Scholar
  2. (2012) B Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 331. doi: 10.1007/978-3-642-16483-5_508Google Scholar
  3. (2012) Doxorubicin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1159. doi: 10.1007/978-3-642-16483-5_1722Google Scholar
  4. (2012) Glioma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1557. doi: 10.1007/978-3-642-16483-5_2423Google Scholar
  5. (2012) Leukemia. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2005. doi: 10.1007/978-3-642-16483-5_3322Google Scholar
  6. (2012) Medullary Breast Carcinoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2199. doi: 10.1007/978-3-642-16483-5_3599Google Scholar
  7. (2012) Multidrug Resistance. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2393. doi: 10.1007/978-3-642-16483-5_3887Google Scholar
  8. (2012) Pharmacokinetics. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2845. doi: 10.1007/978-3-642-16483-5_4500Google Scholar
  9. (2012) Progesterone. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2990. doi: 10.1007/978-3-642-16483-5_4753Google Scholar
  10. (2012) Serotonin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3389. doi: 10.1007/978-3-642-16483-5_5262Google Scholar
  11. (2012) Verapamil. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3906. doi: 10.1007/978-3-642-16483-5_6179Google Scholar
  12. (2012) Vinblastine. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3907. doi: 10.1007/978-3-642-16483-5_6186Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Laboratory of Precision NanoMedicine, Department of Cell Research and Immunology, George S. Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael
  2. 2.Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael
  3. 3.Center for Nanoscience and NanotechnologyTel Aviv UniversityTel AvivIsrael