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Amine Oxidases

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  • First Online:
Encyclopedia of Cancer

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Definition

Amine oxidases (AOs) are a class of enzymes which is heterogeneous in terms of structure, catalytic mechanisms, and substrate specificity. Biogenic amines, a group of naturally occurring, biologically active amines, such as monoamines (norepinephrine, histamine, tyramine, dopamine, and serotonin) and polyamines (putrescine, spermidine, spermine) are oxidatively deaminated by AOs in a reaction that consumes O2 to produce the corresponding aldehydes, amines with a shorter chain, ammonium ions, and hydrogen peroxide (H2O2).

Characteristics

Two classes of AOs can be described, which contain different prosthetic groups: the FAD-dependent AOs (FAD-AOs) containing the flavin adenin dinucleotide (FAD), and the copper-dependent AOs (Cu-AOs) containing copper and an organic cofactor produced by the copper self-catalyzed posttranslational oxidation of a tyrosine residue, i.e., TPQ (trihydroxyphenylalanine quinone), or LTQ characteristic of lysyl oxidase (LXAO).

The FAD-AOs are...

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References

  • Bachrach U, Eilon G (1967) Interaction of oxidized polyamine with DNA. I. Evidence of the formation of cross-links. Biochim Biophys Acta 145:418–4263

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  • Floris G, Mondovì B (eds) (2009) Copper amine oxidases. Structures, catalytic mechanisms, and role in pathophysiology. CRC Press/Taylor & Francis Group, Boca Raton

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  • Toninello A, Pietrangeli P, De Marchi U et al (2006) Amine oxidases in apoptosis and cancer. Biochim Biophys Acta 1765:1–13

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See Also

  • (2012) Allergic disease. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 137. doi: 10.1007/978-3-642-16483-5_190

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  • (2012) Differentiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1113. doi: 10.1007/978-3-642-16483-5_1616

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  • (2012) Postischemic Reperfusion. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2965. doi: 10.1007/978-3-642-16483-5_4692

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Author information

Authors and Affiliations

  1. Department of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, Rome, Italy

    Bruno Mondovì, Paola Pietrangeli & Lucia Marcocci

  2. Department of Biological Chemistry, University of Padua, Viale G. Colombo 3, 35121, Padua, Italy

    Antonio Toninello

Authors
  1. Bruno Mondovì
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  2. Paola Pietrangeli
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  3. Lucia Marcocci
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  4. Antonio Toninello
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Corresponding author

Correspondence to Bruno Mondovì .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Mondovì, B., Pietrangeli, P., Marcocci, L., Toninello, A. (2014). Amine Oxidases. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_222-10

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_222-10

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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