Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fluorescence Diagnostics

  • Peter M. Schlag
  • K. Thomas Moesta
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2217-3

Synonyms

Definition

Fluorescence diagnostics are procedures designed to detect neoplastic tissues based upon spectroscopic recognition of tissue-specific accumulations of natural or artificial fluorescing molecules (fluorophores).

Characteristics

Certain fluorescing dyes selectively accumulate in cancer cells and may, since fluorescing molecules are very rare in the biological environment, serve for sensitive detection of early cancerous lesions in human tissues without interfering with tissue integrity. Some of the dyes used for photodynamic therapypresent a strong fluorescence, and since they localize to malignant tumors, early attempts were made to use these dyes for tumor diagnosis. Polyporphimer sodium (Photofrin®), for example, is a more effective purified fraction of the classical hematoporphyrinderivate (HpD), which has now obtained clinical approval for various indications in several...

Keywords

Barrett Esophagus White Light Endoscopy Background Subtraction Technique Fluorescence Endoscopy Invasive Lung Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kriegmair M, Baumgartner R, Lumper W et al (1996) Early clinical experience with 5-aminolevulinic acid for the photodynamic therapy of superficial bladder cancer. Br J Urol 77:667–671CrossRefPubMedGoogle Scholar
  2. Lam S, Kennedy T, Unger M et al (1998) Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 13:696–702CrossRefGoogle Scholar
  3. Mang TS, McGinnis C, Liebow C et al (1993) Fluorescence detection of tumors. Early diagnosis of microscopic lesions in preclinical studies. Cancer 71:269–276CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Comprehensive Cancer CenterCharité Campus MitteBerlinGermany
  2. 2.Klinik für Chirurgie und Chirurgische OnkologieCharité Universitätsmediyin BerlinBerlinGermany