Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fibrinogen

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2171-2

Definition

Is a major plasma glycoprotein (350 kDa) that plays an important role in blood clotting, cellular and matrix interactions, inflammation, wound healing, and neoplasia.

Characteristics

Fibrinogen is a 340 kDa glycoprotein that consists of two identical disulfide-linked subunits. Each subunit is composed of three nonidentical polypeptide chains: alpha, beta, and gamma. The beta and gamma chains have conserved C-terminal domains of about 250 amino acid residues (designated βC and γC, respectively). The crystal structure of the isolated γC domain, as well as that of the γC and βC domains in the fibrinogen D fragment, revealed that both domains are similarly folded. A minor 420 kDa form of fibrinogen (fibrinogen-420) has an alternative extended form of the alpha chain (αE), which has a C-terminal domain (designated αEC) whose sequence and fold are highly homologous to those of the βC and γC domains. Fibrinogen binds to CD54 (ICAM-1) through the first IgG domain (8KVILPRGGSVLVTC21...

Keywords

Adult Respiratory Distress Syndrome Endothelial Monolayer Cell Adhesion Receptor Extracellular Serine Protease Vascular Endothelial Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Akakura N, Hoogland C, Takada YK et al (2006) The C-terminal globular domain of fibrinogen γ chain suppresses angiogenesis and tumor growth. Cancer Res 66(19):9691–9697CrossRefPubMedGoogle Scholar
  2. Dang CV, Bell WR, Kaiser D et al (1985) Disorganization of cultured vascular endothelial cell monolayers by fibrinogen fragment D. Science 227:1487–1490CrossRefPubMedGoogle Scholar
  3. Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110:673–687CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.UC Davis School of MedicineSacramentoUSA