Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

AME Transcription Factor

  • Vitalyi Senyuk
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_217-2

Synonyms

Definition

AME is an aggressive oncoprotein (chimeric transcription factor) associated with several types of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative disorders (MPD).

Characteristics

The legendary discovery of chromosomal translocations by Janet D. Rowley in 1972 has revolutionized leukemia research and therapy by allowing biological interrogation and classification of these disorders. Several recurring translocations have been identified and the participating genes cloned and characterized at the molecular level. One such recurring abnormality is the balanced translocation between the long arms of chromosomes 3 and 21, t(3;21)(q26;q22), originally discovered in a patient with therapy-related chronic myelogenous leukemia (CML) which is classified as an MPD.

The t(3;21) is a complicated chromosomal rearrangement that employs a mechanism of intergenic splicing to generate several fusion genes of which AME...

Keywords

Acute Myeloid Leukemia Acute Myeloid Leukemia Patient Essential Thrombocythemia Chronic Myelogenous Leukemia Patient Positive Acute Myeloid Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Nucifora G, Rowley JD (1995) AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86:1–14PubMedGoogle Scholar
  2. Nucifora G, Laricchia-Robbio L, Senyuk V (2006) EVI1 and hematopoietic disorders: history and perspectives. Gene 368:1–11CrossRefPubMedGoogle Scholar
  3. Rubin CM, Larson RA, Bitter MA et al (1987) Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia. Blood 70:1338–1342PubMedGoogle Scholar
  4. Yin CC, Cortes J, Barkoh B et al (2006) t(3;21)(q26;q22) in myeloid leukemia. Cancer 106:1730–1738CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Medicine (M/C 737), College of Medicine Research BuildingUniversity of Illinois at ChicagoChicagoUSA