Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fever of Unknown Origin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2162-2

Synonyms

Definition

Fever of unknown origin is a clinical syndrome of fever that does not resolve spontaneously within 3 weeks, and the cause remains unknown after extensive work-up. Fever is defined as an elevation of the body temperature that exceeds the normal daily variation. The hypothalamus controls the body temperature, and a normal body temperature is ordinarily maintained because the hypothalamic thermal regulatory center balances the excess heat production derived from metabolic activities in the muscles and the liver with heat dissipation from the skin and lungs. Normally, healthy adult individuals have a mean oral temperature of 36.8 °C ± 0.4 °C. The temperature is a little bit higher in the evening. Fever of unknown origin is an important clinical challenge. In 1961 Petersdorf and Beeson (1961) defined it in their first report as an illness characterized by fever of...

Keywords

Multiple Myeloma Unknown Origin Kidney Cancer Standardize Incidence Rate Occult Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Arnow PM, Flaherty JP (1997) Fever of unknown origin. Lancet 350:575–580CrossRefPubMedGoogle Scholar
  2. Mourad O, Palda V, Detsky AS (2003) A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med 163:545–551CrossRefPubMedGoogle Scholar
  3. Petersdorf RG, Beeson PB (1961) Fever of unexplained origin: report on 100 cases. Medicine (Baltimore) 40:1–30CrossRefGoogle Scholar
  4. Sørensen HT, Mellemkjær L, Skriver MV et al (2005) Fever of unknown origin and cancer: a population-based study. Lancet Oncol 6:851–855CrossRefPubMedGoogle Scholar
  5. Vanderschueren S, Knockaert D, Adriaenssens T et al (2003) From prolonged febrile illness to fever of unknown origin: the challenge continues. Arch Intern Med 163:1033–1041CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Clinical EpidemiologyAarhus University HospitalAarhus CDenmark