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Deferasirox

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 51 Accesses

Synonyms

Exjade® ; ICL670A

Definition

Deferasirox is a rationally designed orally administered iron chelator.

Characteristics

Pharmacological Properties

Deferasirox is a rationally designed oral iron chelator.

Deferasirox is indicated for the treatment of chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as β-thalassemia and other chronic anemias. It was approved by the United States Food and Drug Administration (FDA) in November 2005. It is the first oral medication approved in the USA for this purpose.

Its low molecular weight and high lipophilicity allows the drug to be taken orally unlike deferoxamine (DFO) which has to be administered by IV route. The half-life of deferasirox is between 8 and 16 h allowing once a day dosing. Deferasirox is capable of removing iron from cells as well as removing iron from the blood. Deferasirox is a tridentate iron chelator with high affinity for iron as Fe3+; two molecules of deferasirox bind to...

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References

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Authors and Affiliations

  1. Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel

    Galit Granot

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  1. Galit Granot
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  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Granot, G. (2015). Deferasirox. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_2153-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_2153-3

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