AFP or alpha-fetoprotein is a serum protein of mammalian fetuses that is hardly detectable in healthy adults. Its reoccurrence in serum of adults may often attest to specific malignancy especially in high-risk patients, such as those with hepatocellular carcinomas (hepatocellular carcinoma, hepatoblastoma) and chronic hepatitis B or C virus infection (hepatitis-associated hepatocellular carcinoma). It also serves in evaluation (serum biomarkers, surrogate endpoints) of therapy and disease progress in patients with embryonal carcinomas (germ cell tumors, platinum-refractory testicular germ cell tumors).
The studies of fetal serum proteins came from different corners: from researchers interested primarily in the development of proteins and from those studying proteins of tumor-bearing laboratory animals. These two groups were...
KeywordsTesticular Cancer Fetal Serum Precipitin Line Fetal Protein Immunochemical Technique
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