Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Alpha-Fetoprotein

  • Karel Kithier
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-3-642-27841-9_206-3

Synonyms

Definition

AFP or alpha-fetoprotein is a serum protein of mammalian fetuses that is hardly detectable in healthy adults. Its reoccurrence in serum of adults may often attest to specific malignancy especially in high-risk patients, such as those with hepatocellular carcinomas (hepatocellular carcinoma, hepatoblastoma) and chronic hepatitis B or C virus infection (hepatitis-associated hepatocellular carcinoma). It also serves in evaluation (serum biomarkers, surrogate endpoints) of therapy and disease progress in patients with embryonal carcinomas (germ cell tumors, platinum-refractory testicular germ cell tumors).

Characteristics

The studies of fetal serum proteins came from different corners: from researchers interested primarily in the development of proteins and from those studying proteins of tumor-bearing laboratory animals. These two groups were...

Keywords

Testicular Cancer Fetal Serum Precipitin Line Fetal Protein Immunochemical Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Abelev GI (1971) Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res 14:295–358, PubMedCrossRefCrossRefPubMedGoogle Scholar
  2. Kithier K, Poulik MD (1972) Comparative studies of bovine alpha-fetoprotein and fetuin. Biochim Biophys Acta 278:505–516, PubMedCrossRefCrossRefPubMedGoogle Scholar
  3. Kithier K, Prokes J (1966) Fetal alpha-1 globulin of rat serum. Biochim Biophys Acta 127:390–399, PubMedCrossRefCrossRefPubMedGoogle Scholar
  4. Kithier K, Houstek J, Masopust J et al (1966) Occurrence of a specific foetal protein in a primary liver carcinoma. Nature 212:414, PubMedCrossRefCrossRefPubMedGoogle Scholar
  5. Masopust J, Kithier K, Radl J et al (1968) Occurrence of fetoprotein in patients with neoplasms and non-neoplastic diseases. Int J Cancer 3:364–373, PubMedCrossRefCrossRefPubMedGoogle Scholar

See Also

  1. (2012) Germ cell tumors. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1541. doi:10.1007/978-3-642-16483-5_6905Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyWayne State University School of MedicineDetroitUSA