Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ets Transcription Factors

  • Jürgen Dittmer
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2034-2


Ets transcription factors are defined by a unique DNA-binding domain, the ETS domain, which specifically interacts with an ∼10 bp long DNA sequence containing a 5′-GGAA/T-3′ core motif (Fig. 1) Ets stands for E26 transformation specific or E26, as the Ets sequence (v-ets) was first identified in the genome of the avian retrovirus E26. c-Ets1, closely related to v-ets, was the first cellular Ets protein that was discovered. More than 30 different Ets proteins have been identified, found throughout the metazoan world including mammals, sea urchins, worms, and insects. Currently, 27 human Ets proteins are known. The Ets family is subdivided into subfamilies based on the similarity in the ETS domain (Fig. 2).


Pointed Domain Pacinian Corpuscle Sterile Alpha Motif Ewing Tumor Alveolar Morphogenesis 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Klinik für GynäkologieUniversität Halle-WittenbergHalle (Saale)Germany