Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ets Transcription Factors

  • Jürgen Dittmer
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2034-2

Definition

Ets transcription factors are defined by a unique DNA-binding domain, the ETS domain, which specifically interacts with an ∼10 bp long DNA sequence containing a 5′-GGAA/T-3′ core motif (Fig. 1) Ets stands for E26 transformation specific or E26, as the Ets sequence (v-ets) was first identified in the genome of the avian retrovirus E26. c-Ets1, closely related to v-ets, was the first cellular Ets protein that was discovered. More than 30 different Ets proteins have been identified, found throughout the metazoan world including mammals, sea urchins, worms, and insects. Currently, 27 human Ets proteins are known. The Ets family is subdivided into subfamilies based on the similarity in the ETS domain (Fig. 2).

Keywords

Pointed Domain Pacinian Corpuscle Sterile Alpha Motif Ewing Tumor Alveolar Morphogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Dittmer J (2003) The biology of the Ets1 proto-oncogene. Mol Cancer 2:29CrossRefPubMedPubMedCentralGoogle Scholar
  2. Foos G, Hauser CA (2004) The role of Ets transcription factors in mediating cellular transformation. In: Handbook of experimental pharmacology, vol 166, Transcription factors. Springer, Berlin/Heidelberg/New York, pp 259–275Google Scholar
  3. Seth A, Watson DK (2005) ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 41:2462–2478CrossRefPubMedGoogle Scholar
  4. Tootle TL, Rebay I (2005) Post-translational modifications influence transcription factor activity: a view from the ETS superfamily. Bioessays 27:285–298CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Klinik für GynäkologieUniversität Halle-WittenbergHalle (Saale)Germany