Ether à-go-go Potassium Channels
Ether à-go-go potassium channels are transmembrane proteins opening in response to changes in membrane potential and allowing the movement of potassium ions.
Ion transport is crucial for maintaining proper cellular function; this important task is performed by several membrane transporters including ion channels. Among other functions, ion channels play key roles in neurotransmission, muscle contraction, metabolism, sensory transduction, apoptosis, and cell cycle progression. Because of their pivotal role in cellular function, altered expression and/or activity of ion channels leads to several diseases including cardiac arrhythmias, diabetes, and epilepsy, turning these proteins into major drug targets. Participation of ion channels in cell proliferation and cell death makes them not only fundamental elements for the understanding of cancer but also potential clinical tools both for diagnosis and therapy of cancer.
KeywordsAcute Myeloid Leukemia Endometrial Cancer Potassium Channel Vascular Endothelial Growth Factor Secretion Oncogenic Property
- Downie BR, Sánchez A, Knötgen H et al (2009) Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem 238:6234–6240Google Scholar
- García-Quiroz J, García-Becerra R, Santos-Martínez N, Barrera D, Ordaz-Rosado D, Avila E, Halhali A, Villanueva O, Ibarra-Sánchez MJ, Esparza-López J, Gamboa-Domínguez A, Camacho J, Larrea F, Díaz L (2014) In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors. BMC Cancer 14:745CrossRefPubMedPubMedCentralGoogle Scholar
- Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME, Ufartes R, Eilers J, Sakaba T, Stühmer W, Pardo LA (2015) KV 10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. J Physiol 593(1):181–196Google Scholar
- Ramírez A, Hinojosa LM, Gonzales J d J, Montante-Montes D, Martínez-Benítez B, Aguilar-Guadarrama R, Gamboa-Domínguez A, Morales F, Carrillo-García A, Lizano M, García-Becerra R, Díaz L, Vázquez-Sánchez AY, Camacho J (2013) KCNH1 potassium channels are expressed in cervical cytologies from pregnant patients and are regulated by progesterone. Reproduction 146:615–623CrossRefPubMedGoogle Scholar
- Simons C, Rash LD, Crawford J, Ma L, Cristofori-Armstrong B, Miller D, Ru K, Baillie GJ, Alanay Y, Jacquinet A, Debray FG, Verloes A, Shen J, Yesil G, Guler S, Yuksel A, Cleary JG, Grimmond SM, McGaughran J, King GF, Gabbett MT, Taft RJ (2015) Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. Nat Genet 47(1):73–77CrossRefPubMedGoogle Scholar
- Ufartes R, Schneider T, Mortensen LS, de Juan Romero C, Hentrich K, Knoetgen H, Beilinson V, Moebius W, Tarabykin V, Alves F, Pardo LA, Rawlins JN, Stuehmer W (2013) Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Hum Mol Genet 22(11):2247–2262CrossRefPubMedPubMedCentralGoogle Scholar