Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ether à-go-go Potassium Channels

  • Javier CamachoEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2028-8

Synonyms

Definition

Ether à-go-go potassium channels are transmembrane proteins opening in response to changes in membrane potential and allowing the movement of potassium ions.

Characteristics

Ion transport is crucial for maintaining proper cellular function; this important task is performed by several membrane transporters including ion channels. Among other functions, ion channels play key roles in neurotransmission, muscle contraction, metabolism, sensory transduction, apoptosis, and cell cycle progression. Because of their pivotal role in cellular function, altered expression and/or activity of ion channels leads to several diseases including cardiac arrhythmias, diabetes, and epilepsy, turning these proteins into major drug targets. Participation of ion channels in cell proliferation and cell death makes them not only fundamental elements for the understanding of cancer but also potential clinical tools both for diagnosis and therapy of cancer.

Ether à-go-...

Keywords

Acute Myeloid Leukemia Endometrial Cancer Potassium Channel Vascular Endothelial Growth Factor Secretion Oncogenic Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of PharmacologyCentro de Investigación y de Estudios Avanzados del I.P.N.Mexico City, D.F.Mexico