Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Estrogenic Hormones

  • Elwood V. Jensen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2018-2

Definition

Estrogens are steroid sex hormones produced chiefly in the ovary and responsible for development and function of the female reproductive tissues such as the uterus and mammary gland. Smaller amounts are also produced by the testis in the male and the adrenal gland in both sexes and contribute to maintenance of bone density and function of cardiovascular and neurological tissues. Estrogenic hormones play a role in both the genesis and treatment of several types of cancer. In general, estrogen-related tumors are those involving tissues of the female reproductive tract, although estrogens produce liver cancers in the hamster and are probably a factor in their occurrence in humans.

Characteristics

Etiology

Carcinogenesis is known to be a multistep process (multistep development), involving both initiation (alteration of DNA) and promotion (proliferation of the altered cells). It is generally agreed that the principal effect of estrogenic hormones is on the promotion stage,...

Keywords

Breast Cancer Cervical Cancer Endometrial Cancer Estrogenic Hormone Unopposed Estrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Holland JF, Frei E III, Bast RC Jr et al (2000) Cancer medicine, 5th edn. BC Decker, HamiltonGoogle Scholar
  2. Jensen EV (1999) Oncology. In: Oettel M, Schillinger E (eds) Handbook of experimental pharmacology vol 135/II, estrogens and antiestrogens II pharmacology and clinical application. Springer, Berlin/Heidelberg/New York, pp 195–203Google Scholar
  3. Li JJ, Li SA, Gustafsson J-Å et al (1996) Hormonal carcinogenesis II. Springer, Berlin/Heidelberg/New YorkGoogle Scholar
  4. Lindsay R, Dempster DW, Jordan VC (1997) Estrogens and antiestrogens: basic and clinical aspects. Lippincott-Raven, Philadelphia/New YorkGoogle Scholar
  5. Parl FF (2000) Estrogens, estrogen receptor and breast cancer. Ios Press, AmsterdamGoogle Scholar

See Also

  1. (2012) Antiestrogens. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 209. doi:10.1007/978-3-642-16483-5_318Google Scholar
  2. (2012) Aromatase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 276. doi:10.1007/978-3-642-16483-5_394Google Scholar
  3. (2012) Biosynthesis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 415. doi:10.1007/978-3-642-16483-5_647Google Scholar
  4. (2012) Cytotoxic chemotherapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1058. doi:10.1007/978-3-642-16483-5_1499Google Scholar
  5. (2012) Endocrine ablation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1223. doi:10.1007/978-3-642-16483-5_1871Google Scholar
  6. (2012) Endometrium. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1239. doi:10.1007/978-3-642-16483-5_1886Google Scholar
  7. (2012) Endoplasmic reticulum. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1240. doi:10.1007/978-3-642-16483-5_1887Google Scholar
  8. (2012) Glucocorticoids. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1558. doi:10.1007/978-3-642-16483-5_2429Google Scholar
  9. (2012) Hormone replacement therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 1733-1734. doi:10.1007/978-3-642-16483-5_2815Google Scholar
  10. (2012) Mastectomy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2177. doi:10.1007/978-3-642-16483-5_3548Google Scholar
  11. (2012) Teratogenic. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3651. doi:10.1007/978-3-642-16483-5_5731Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.National Institute of HealthBethesdaUSA