Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Estrogen Receptor

  • Gwendal Lazennec
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2014-2

Synonyms

Definition

Estrogen receptors are represented by two main members (estrogen receptor alpha, ERα, and estrogen receptor beta, ERβ), which bind estrogens. These receptors are mainly nuclear, even though membrane receptors are also suspected to exist. Nuclear estrogen receptors belong to a large family of nuclear receptors, which are ligand-activated transcription factors able to modulate the expression of different genes.

Characteristics

History

The mediators of estrogens, namely, estrogen receptors, remained elusive until the synthesis of radiolabeled estradiolby Jensen and Jacobsen in 1960, which allowed the identification of such receptors. But it took more than 20 years, with the development at a high rate of molecular biology techniques, to have the first cDNA encoding estrogen receptor (α) cloned by the group of Chambon in Strasbourg. In 1996, when most of nuclear receptors had already been cloned, a great...

Keywords

Ovarian Cancer Estrogen Receptor Endometrial Cancer Mammary Gland Development Estrogen Receptor Beta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Deroo BJ, Korach KS (2006) Estrogen receptors and human disease. J Clin Invest 116:561–570CrossRefPubMedPubMedCentralGoogle Scholar
  2. Jensen EV (2005) The contribution of “alternative approaches” to understanding steroid hormone action. Mol Endocrinol 19:1439–1442CrossRefPubMedGoogle Scholar
  3. Levin ER (2005) Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 19:1951–1959CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) Coactivators. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 886. doi: 10.1007/978-3-642-16483-5_1238Google Scholar
  2. (2012) Estrogens. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1333. doi: 10.1007/978-3-642-16483-5_2019Google Scholar
  3. (2012) Nuclear Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2571. doi: 10.1007/978-3-642-16483-5_4157Google Scholar
  4. (2012) Transcription Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi: 10.1007/978-3-642-16483-5_5901Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.INSERMMontpellierFrance