Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Esophageal Cancer

  • Ruggero MontesanoEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2009-2


Esophageal cancer comprises two main types of malignant epithelial neoplasms: squamous cell carcinoma, originating from the lining squamous epithelium of the esophagus, and adenocarcinoma (also called Barrett’s adenocarcinoma), originating from metaplastic columnar epithelium in the lower part of the esophagus.


Esophageal cancer is the sixth most frequent cancer worldwide. In 2001, the estimated number of deaths due to esophageal cancer amounted to about 338,000 out of a total of 6.2 million cancer deaths. Of those, more than 80 % occurred in developing countries, the majority being squamous cell carcinomas. The occurrence of this cancer varies greatly in different parts of the world, with areas of high mortality rate per year in regions of South Africa, Northeast of Iran and China (30 or more per 100,000 in males and 10 per 100,000 in females). In Europe or USA, the age standardized annual mortality of squamous cell carcinoma is no more than 5 in males and 1...


Squamous Cell Carcinoma Esophageal Cancer Squamous Epithelium Malignant Epithelial Neoplasm Normal Squamous Epithelium 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.International Agency for Research on CancerLyonFrance