Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

ERM Proteins

  • Ling RenEmail author
  • Chand Khanna
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1990-2



The ERM family consists of three closely related proteins, ezrin, radixin, and moesin. ERM proteins are cell membrane and cytoskeleton linker proteins.


History, Structure, and Sequence

Ezrin, the prototype ERM protein, is a 585-amino acid polypeptide, first identified as a constituent of microvilli and shown to be present in actin-containing surface structure on a wide variety of cells. ERM proteins share homology in sequence structure and function. They are composed of three domains: an N-terminal globular domain, an extended α-helical domain, and a charged C-terminal domain. The N-terminal domain of ERM proteins is highly conserved and is also found in merlin, band 4.1 proteins, and members of the band 4.1 superfamily. This domain is called FERM (four point one protein, ezrin, radixin, moesin) domain. The crystal structure of moesin revealed that the FERM domain is composed of three structural modules that, together, form a...


Lung Adenocarcinoma Myotonic Dystrophy Ferm Domain Ezrin Protein Invade Tumor Cell 
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  1. Bretscher A, Chambers D, Nguyen R et al (2000) ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Annu Rev Cell Dev Biol 16:113–143PubMedCrossRefGoogle Scholar
  2. Bretscher A, Edwards K, Fehon RG (2002) ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 3:586–599PubMedCrossRefGoogle Scholar
  3. McClatchey AI (2003) Merlin and ERM proteins: unappreciated roles in cancer development? Nat Rev Cancer 3:877–883PubMedCrossRefGoogle Scholar
  4. Tsukita S, Yonemura S (1999) Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J Biol Chem 274:34507–34510PubMedCrossRefGoogle Scholar
  5. Vaheri A, Carpen O, Heiska L et al (1997) The ezrin protein family: membrane-cytoskeleton interactions and disease associations. Curr Opin Cell Biol 9:659–666PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2013

Authors and Affiliations

  1. 1.Pediatric Oncology BranchNational Cancer Institute, Center for Cancer ResearchBethesdaUSA