Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Epstein–Barr Virus Latent Membrane Protein 1

  • Martina Vockerodt
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1979-2

Definition

The latent membrane protein 1 (LMP1) of the Epstein–Barr virus (EBV) is an oncogene that is expressed during latent EBV infection. LMP1 is sufficient for the transformation of rodent fibroblast cells and is essential for efficient B cell transformation. LMP1 mimics a constitutively active tumor necrosis factor (TNF) receptor and interacts with and deregulates the signal transduction network of the host cell leading to altered cell survival, differentiation, and phenotypic changes.

Characteristics

EBV belongs to the family of gamma herpes viruses; it infects humans and establishes a latent infection for the lifetime of the individual. Infection in childhood is usually asymptomatic, but in young adults can lead to infectious mononucleosis. Due to its association with B cell tumors as Burkitt lymphoma (BL), Hodgkin disease/lymphoma(HL), posttransplant lymphoproliferative disorder, and epithelial tumors as nasopharyngeal carcinoma (NPC) and gastric carcinoma, EBV was the first...

Keywords

Burkitt Lymphoma Active Tumor Necrosis Factor Virus Latent Gene Rodent Fibroblast Virus Latent Membrane Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Young LS, Rickinson AB (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4:757–768CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pediatrics I, Children’s HospitalGeorg-August University of GottingenGottingenGermany