Epstein–Barr Virus Latent Membrane Protein 1
The latent membrane protein 1 (LMP1) of the Epstein–Barr virus (EBV) is an oncogene that is expressed during latent EBV infection. LMP1 is sufficient for the transformation of rodent fibroblast cells and is essential for efficient B cell transformation. LMP1 mimics a constitutively active tumor necrosis factor (TNF) receptor and interacts with and deregulates the signal transduction network of the host cell leading to altered cell survival, differentiation, and phenotypic changes.
EBV belongs to the family of gamma herpes viruses; it infects humans and establishes a latent infection for the lifetime of the individual. Infection in childhood is usually asymptomatic, but in young adults can lead to infectious mononucleosis. Due to its association with B cell tumors as Burkitt lymphoma (BL), Hodgkin disease/lymphoma(HL), posttransplant lymphoproliferative disorder, and epithelial tumors as nasopharyngeal carcinoma (NPC) and gastric carcinoma, EBV was the first...