Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Epstein-Barr Virus

  • Evelyne ManetEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1978-2

Synonyms

Definition

Epstein-Barr virus (EBV) was the first virus isolated from a human tumor, Burkitt’s lymphoma (BL). EBV is a lymphotropic γ-herpesvirus widely spread in the human population: 90–95 % of adults have antibodies against the virus. In the majority of cases, the primary infection occurs within the first 3 years of life and is asymptomatic. When EBV infection occurs later in life, usually during adolescence, it results in the symptomatic illness known as infectious mononucleosis (IM). Infected individuals carry the virus all their life, in a very low number of lymphoid B cells (probably resting B cells) in their peripheral blood and lymphatic organs. Intermittent viral shedding occurs into the saliva, due to viral replication in the oropharyngeal lymphoid or epithelial tissues: saliva is the main transmission route of the virus. Since its first discovery in 1964 in Burkitt’s lymphoma tumor, EBV has been found to be associated with several...

Keywords

Hodgkin Disease Undifferentiated Nasopharyngeal Carcinoma Rodent Fibroblast Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Münz C (ed) (2015a) Epstein Barr virus volume 1. One herpes virus: many diseases. In: Current topics in microbiology and immunology, vol 390. Springer International PublishingGoogle Scholar
  2. Münz C (ed) (2015b) Epstein Barr virus volume 2. One herpes virus: many diseases. In: Current topics in microbiology and immunology, vol 391. Springer International PublishingGoogle Scholar
  3. Rickinson AB (2014) Co-infections, inflammation and oncogenesis: future directions for EBV research. Semin Cancer Biol 26:99–115CrossRefPubMedGoogle Scholar
  4. Thorley-Lawson DA, Hawkins JB, Tracy SI, Shapiro ME (2013) The pathogenesis of Epstein-Barr virus persistent infection. Curr Opin Virol 3(3):227–232CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) Burkitt Lymphoma Cell Lines. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 575. doi: 10.1007/978-3-642-16483-5_754Google Scholar
  2. (2012) Lymphoblastoid Cell Lines. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 2122-2123. doi: 10.1007/978-3-642-16483-5_3454Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.CIRI-International Center for Infectiology Research, INSERM U1111, Université Lyon 1, ENS de LyonLyonFrance