Epstein-Barr virus (EBV) was the first virus isolated from a human tumor, Burkitt’s lymphoma (BL). EBV is a lymphotropic γ-herpesvirus widely spread in the human population: 90–95 % of adults have antibodies against the virus. In the majority of cases, the primary infection occurs within the first 3 years of life and is asymptomatic. When EBV infection occurs later in life, usually during adolescence, it results in the symptomatic illness known as infectious mononucleosis (IM). Infected individuals carry the virus all their life, in a very low number of lymphoid B cells (probably resting B cells) in their peripheral blood and lymphatic organs. Intermittent viral shedding occurs into the saliva, due to viral replication in the oropharyngeal lymphoid or epithelial tissues: saliva is the main transmission route of the virus. Since its first discovery in 1964 in Burkitt’s lymphoma tumor, EBV has been found to be associated with several...
KeywordsHodgkin Disease Undifferentiated Nasopharyngeal Carcinoma Rodent Fibroblast Cell Line
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