A group of microtubule-targeting agents, like taxanes, and vinca alkaloids. Epothilones were originally identified as metabolites produced by the common soil myxobacterium Sorangium cellulosum. They were found initially to have a narrow antifungal spectrum, but they also were found too toxic for use as an antifungal. Subsequently, their anticancer properties were detected. They are important and powerful options in the management of breast cancer and prostate cancer. The epothilones are a new class of cytotoxic molecules, including epothilone A, epothilone B, and epothilone D, identified as potential chemotherapy drugs. Early studies in cancer cell lines and in human cancer patients indicate superior efficacy to the taxanes. Their mechanism of action is similar to that of the taxanes, but their chemical structure is simpler and they are more soluble in water. Although taxane-based therapy has been used successfully, its effectiveness is often compromised by the emergence of d...
KeywordsBreast Cancer Prostate Cancer Vinca Alkaloid Anticancer Property Common Soil
- (2012) Microtubule. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2308. doi: 10.1007/978-3-642-16483-5_3734Google Scholar
- (2012) Taxanes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3614–3615. doi: 10.1007/978-3-642-16483-5_6648Google Scholar
- (2012) Vinca alkaloids. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3908. doi: 10.1007/978-3-642-16483-5_6187Google Scholar