Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Allogeneic Cell Therapy

  • Wolfgang Herr
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_196-2

Synonyms

Definition

Allogeneic cell therapy consists of chemoradiotherapeutic conditioning therapy followed by transplantation of hematopoietic stem cells and lymphocytes isolated from allogeneic healthy donors to generate an effective graft-versus-malignancy immune response in patients with treatment-refractory malignant disorders.

Characteristics

Rationale

Allogeneic hematopoietic stem cell transplantation (HSCT) aims to break autologous immunotolerance toward malignant cells in tumor-bearing patients. The treatment approach is based on the alloreactive graft-versus-malignancy effect that is mainly mediated by T cells of donor origin. These donor T cells are infused together with allogeneic hematopoietic stem cells (HSC) at the time of transplantation or originate from donor HSC in the patient thereafter. Allogeneic HSCT is capable of inducing long-term...

Keywords

Human Leukocyte Antigen Hematopoietic Stem Cell Transplantation Allogeneic Hematopoietic Stem Cell Transplantation Donor Lymphocyte Infusion Human Leukocyte Antigen Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Universitätsklinikum RegensburgRegensburgGermany