Allogeneic Cell Therapy
Allogeneic cell therapy consists of chemoradiotherapeutic conditioning therapy followed by transplantation of hematopoietic stem cells and lymphocytes isolated from allogeneic healthy donors to generate an effective graft-versus-malignancy immune response in patients with treatment-refractory malignant disorders.
Allogeneic hematopoietic stem cell transplantation (HSCT) aims to break autologous immunotolerance toward malignant cells in tumor-bearing patients. The treatment approach is based on the alloreactive graft-versus-malignancy effect that is mainly mediated by T cells of donor origin. These donor T cells are infused together with allogeneic hematopoietic stem cells (HSC) at the time of transplantation or originate from donor HSC in the patient thereafter. Allogeneic HSCT is capable of inducing long-term...