Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Epidermal Growth Factor-like Ligands

  • Aleksandra Glogowska
  • Thomas Klonisch
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1933-2



Epidermal growth factor (EGF-)-like family members bind to and activate EGF receptor tyrosine kinases ErbB-1, −2, −3, and −4, also named HER1-4. This triggers the activation of intracellular signal transduction pathways, resulting in cellular proliferation and differentiation. All members of the EGF-like family are produced as membrane-anchored precursors and are processed and released through the action of specific membrane-bound proteolytic enzymes of the sheddase family.

Epidermal Growth Factor- (EGF-) like familyconsists of at least twelve members: Epidermal growth factor (EGF), transforming growth factor alpha (TGFα), heparin binding-EGF like growth factor (HB-EGF), amphiregulin(AR), betacellulin (BTC), epiregulin (EPR), epigen, cripto, and neuregulins 1–4 (NRG1-4). These EGF-like members are defined by three characteristics: (a) they display high affinity binding to membrane-bound epidermal growth factor tyrosine...


Epidermal Growth Factor Transform Growth Factor Alpha EGFR Activation Epidermal Growth Factor Expression Breast Adenocarcinoma Cell Line MCF7 
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See Also

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health SciencesUniversity of ManitobaWinnipegCanada