Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Epidermal Growth Factor Inhibitors

  • Deepa S. Subramaniam
  • Marion Hartley
  • Michael Pishvaian
  • Ruth He
  • John L. Marshall
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1931-3


The EGFR receptor (EGFR) is a member of the HER family of receptor tyrosine kinases that includes EGFR itself (ErbB1/HER1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). These proteins are classic membrane-bound tyrosine kinase receptors whose activation is typically ligand dependent. The principal ligands for EGFR are EGF and TGF-α. Other ligands include amphiregulin, heparin-binding EGF, the poxvirus mitogens, epiregulin, and β-cellulin.


EGFR Activation and Downstream Signaling

Receptor activation results in homo- or heterodimerization and autophosphorylation of c-terminal tyrosine residues. Receptor activation enables the docking of cytoplasmic proteins that bind to specific phosphotyrosine residues and initiate several cell signaling pathways. These pathways include the Ras-Raf-MAPK pathway, the PI3K-AKT pathway, the protein kinase C pathway, the STAT pathway, and the src kinase pathway, all of which play important roles in tumor cell proliferation,...


Rectal Cancer National Comprehensive Cancer Network Keyhole Limpet Hemocyanin EGFR Mutation EGFR Activation 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Deepa S. Subramaniam
    • 1
  • Marion Hartley
    • 2
  • Michael Pishvaian
    • 3
  • Ruth He
    • 3
  • John L. Marshall
    • 3
  1. 1.Georgetown University HospitalWashingtonUSA
  2. 2.Ruesch Center for the Cure of Gastrointestinal CancersLombardi Comprehensive Cancer Center, Georgetown UniversityWashingtonUSA
  3. 3.Lombardi Comprehensive Cancer Center, Georgetown UniversityWashingtonUSA