Eph receptors are tyrosine kinases (RTK) bound to the extracellular membrane that function as “switches” that upon activation by ephrin (EFN) ligands initiate signaling cascades that regulate numerous developmental processes, particularly in the vasculature and nervous system.
The name of the Eph receptors is derived from the name of the cell line used to characterize them initially (erythropoietin-producing hepatocellular carcinoma cell line). These receptors and their ephrin (EFN) ligands constitute the largest family of receptor tyrosine kinases (RTK)known to date. Eph receptors are integral membrane proteins with a conserved N-terminal domain responsible for ligand binding, followed by a cysteine-rich region and two fibronectin type III repeats which are essential for dimerization and interactions with other proteins. The intracellular region of these receptors contains a juxtamembrane domain, a conserved kinase domain, a sterile alpha motif (SAM), and...
KeywordsFocal Adhesion Kinase Cytoskeleton Organization Sterile Alpha Motif EphB Receptor Important Tumor Suppressor
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