Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Endosomal Compartments

  • Vincent Dammai
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1892-2



In eukaryotic cells, receptor-mediated endocytosis releases cargo-loaded vesicles at the plasma membrane. The vesicle content pass through a series of discontinuous closed membrane systems called endosomal compartments. In strict sense, endosomal compartments are temporal sorting stations where the fate of endocytosed cargo is determined.


Eukaryotic cells internalize a variety of extracellular material (cargo) either nonspecifically, by phagocytosis and pinocytosis, or selectively through receptor-mediated endocytosis. In phagocytosis, specialized cells (e.g., macrophagesand neutrophils) engulf large particles such as cell debris, bacteria, and viruses. Pinocytosis, exhibited by all cell types, involve uptake of extracellular fluid continually as tiny droplets (micropinocytosis) or sometimes as large droplets (macropinocytosis). By contrast, receptor-mediated...


Early Endosome Late Endosome Endosomal Compartment Primary Vesicle Internal Vesicle 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Dammai-Morgan Scientific Consultants LLCMount PleasantUSA