Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Endosomal Compartments

  • Vincent Dammai
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1892-2

Synonyms

Definition

In eukaryotic cells, receptor-mediated endocytosis releases cargo-loaded vesicles at the plasma membrane. The vesicle content pass through a series of discontinuous closed membrane systems called endosomal compartments. In strict sense, endosomal compartments are temporal sorting stations where the fate of endocytosed cargo is determined.

Characteristics

Eukaryotic cells internalize a variety of extracellular material (cargo) either nonspecifically, by phagocytosis and pinocytosis, or selectively through receptor-mediated endocytosis. In phagocytosis, specialized cells (e.g., macrophagesand neutrophils) engulf large particles such as cell debris, bacteria, and viruses. Pinocytosis, exhibited by all cell types, involve uptake of extracellular fluid continually as tiny droplets (micropinocytosis) or sometimes as large droplets (macropinocytosis). By contrast, receptor-mediated...

Keywords

Early Endosome Late Endosome Endosomal Compartment Primary Vesicle Internal Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Lakadamyali M, Rust MJ, Zhuang X (2006) Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124:997–1009CrossRefPubMedPubMedCentralGoogle Scholar
  2. Rink J, Ghigo E, Kalaidzidis Y et al (2005) Rab conversion as a mechanism of progression from early to late endosomes. Cell 122:735–749CrossRefPubMedGoogle Scholar
  3. Russell MR, Nickerson DP, Odorizzi G (2006) Molecular mechanisms of late endosome morphology, identity and sorting. Curr Opin Cell Biol 18:422–428CrossRefPubMedGoogle Scholar
  4. Stein MP, Dong J, Wandinger-Ness A (2003) Rab proteins and endocytic trafficking: potential targets for therapeutic intervention. Adv Drug Deliv Rev 55:1421–1437CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Dammai-Morgan Scientific Consultants LLCMount PleasantUSA