Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Endocan

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1868-5

Synonyms

Definition

Endocan is a soluble proteoglycan of 50 kDa carrying a single dermatan sulfate chain. This dermatan sulfate proteoglycan has been shown to be overexpressed in cancers and in diseases when endothelium gets challenged. Endocan/ESM-1 is upregulated in the presence of pro-angiogenic molecules, and VEGF-induced endocan secretion is abolished in the presence of antiangiogenic drug. Clearly, endocan/ESM-1 expression is biomarker of endothelial dysfunction and/or vascular remodeling in inflammatory diseases and in cancer.

Characteristics

Endocan, with synonym endothelial cell-specific molecule-1 (ESM-1), was originally cloned from a human endothelial cell cDNA library and described as being secreted by human umbilical vein endothelial cells (HUVEC). Endocan transcripts were detected from a variety of cultured endothelial cells of different origins, i.e., in human coronary artery endothelial cells (HCAEC), human pulmonary...

Keywords

Human Umbilical Vein Endothelial Cell Cell Renal Carcinoma Patient Vasculogenic Mimicry Clear Cell Renal Carcinoma Human Dermal Microvascular Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bechard D, Gentina T, Delehedde M et al (2001) Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity. J Biol Chem 276:48341–48349PubMedGoogle Scholar
  2. Lassalle P, Molet S, Janin A et al (1996) ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. J Biol Chem 271:20458–20464CrossRefPubMedGoogle Scholar
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  4. Sarrazin S, Adam E, Lyon M et al (2006) Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy. Biochim Biophys Acta 1765:25–37PubMedGoogle Scholar
  5. Sarrazin S, Maurage CA, Delmas D et al (2010a) Endocan as a biomarker of endothelial dysfunction in cancers. J Cancer Sci Ther 2:47–52CrossRefGoogle Scholar
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  7. Strasser GA, Kaminker JS, Tessier-Lavigne M (2010) Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood 115:5102–5110CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.INSERM U774Institut Pasteur de LilleLilleFrance
  2. 2.R&D LunginnovCampus de l’Institut Pasteur de LilleLilleFrance