Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Philippe Lassalle
  • Maryse Delehedde
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1868-5



Endocan is a soluble proteoglycan of 50 kDa carrying a single dermatan sulfate chain. This dermatan sulfate proteoglycan has been shown to be overexpressed in cancers and in diseases when endothelium gets challenged. Endocan/ESM-1 is upregulated in the presence of pro-angiogenic molecules, and VEGF-induced endocan secretion is abolished in the presence of antiangiogenic drug. Clearly, endocan/ESM-1 expression is biomarker of endothelial dysfunction and/or vascular remodeling in inflammatory diseases and in cancer.


Endocan, with synonym endothelial cell-specific molecule-1 (ESM-1), was originally cloned from a human endothelial cell cDNA library and described as being secreted by human umbilical vein endothelial cells (HUVEC). Endocan transcripts were detected from a variety of cultured endothelial cells of different origins, i.e., in human coronary artery endothelial cells (HCAEC), human pulmonary...


Human Umbilical Vein Endothelial Cell Cell Renal Carcinoma Patient Vasculogenic Mimicry Clear Cell Renal Carcinoma Human Dermal Microvascular Endothelial Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.INSERM U774Institut Pasteur de LilleLilleFrance
  2. 2.R&D LunginnovCampus de l’Institut Pasteur de LilleLilleFrance