Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Early Genes of Human Papillomaviruses

  • Massimo Tommasino
  • Rosita Accardi
  • Uzma Hasan
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1789-2


Human Papillomavirus (HPV) 16 has six early genes that are transcribed from the same DNA strand. As in other viruses, the function of the early proteins is to alter several cellular events to guarantee the completion of the virus life cycle. In addition, three early proteins, E5, E6, and E7, are also involved in the induction of malignant transformation of the infected cells. The cutaneous HPV types have a similar organization of the early region, with exception that the majority of these types lack the E5.


HPV constitutes of a heterogeneous group of viruses from the Papillomaviridaefamily. The HPV phylogenetic tree has been designed based on the homologous nucleotide sequence of the L1 capsid protein. So far, 92 HPV types have been fully sequenced, of which 60 belong to the alpha genera and the other 32 belong to the beta and gamma genera. Based on their tissue tropism, HPVs can be divided in cutaneous and mucosal HPV types. The mucosal HPV types are...


Pocket Protein Long Control Region Beta HPV38 Pocket Protein Family Disc Large Protein 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Infections and Cancer Biology GroupInternational Agency for Research on CancerLyonFrance
  2. 2.CIRI, Oncoviruses and Innate ImmunityINSERM U1111, Ecole Normale Supérieure, Université de Lyon, CNRS-UMR5308, Hospices Civils de LyonLyonFrance