Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Early B-Cell Factors

  • Daiqing Liao
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1786-2

Synonyms

Definition

Early B-cell factors are a group of DNA-binding transcription factors containing the helix-loop-helix (HLH) domain. Within their highly conserved DNA-binding domain (DBD), a sequence motif consisting of an atypical zinc finger (H-X3-C-X2-C-X5-C) is unique to this family of proteins.

Characteristics

Early B-cell factor 1 (EBF1) was initially isolated in 1993 from the nuclear extracts of a murine pre-B-cell line through oligonucleotide affinity chromatography. The DNA sequence of the oligonucleotide was derived from the promoter of the mb-1 gene, encoding an immunoglobulin-associated protein that is only expressed in the early stages of B-lymphocyte differentiation. EBF1 is essential for B-cell development, as mice lacking EBF1gene do not produce functional B cells and immunoglobulins. The cDNA encoding a related factor called Olf-1 was...

Keywords

Viral Integration Site Ecotropic Viral Integration Site Human Acute Myelogenous Leukemia Neuronal Transcription Factor Ecotropic Viral Integration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Liberg D, Sigvardsson M, Akerblad P (2002) The EBF/Olf/Collier Family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers. Mol Cell Biol 22:8389–8397CrossRefPubMedPubMedCentralGoogle Scholar
  2. Zardo G, Tiirikainen MI, Hong C et al (2002) Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet 32:453–458CrossRefPubMedGoogle Scholar
  3. Zhao LY, Niu Y, Santiago A et al (2006) An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. Cancer Res 66:9445–9452CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Anatomy and Cell Biology, UF Health Cancer CenterUniversity of Florida College of MedicineGainesvilleUSA