Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

E-Cadherin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1777-2

Synonyms

Definition

E-cadherin, a 120 kDa molecule, is a prototypical member of the classical cadherin family of single-pass transmembrane proteins that mediate calcium-dependent cell-cell adhesion. Normally, epithelial cells are tightly interconnected through several junctional structures, including adherens junctions, tight junctions, and desmosomes. E-cadherin is the main adhesion molecule of the adherens junctions of epithelial cells, and via catenins it is linked to the underlying actin cytoskeleton. Two other members of the cadherin family, desmoglein and desmocollin, mediate adhesion in desmosomes. Via plakoglobin and desmoplakin, they are connected to intermediate cytoskeletal filaments. Thus, E-cadherin and other members of the cadherin family play a crucial role in establishing and maintaining the integrity of epithelial tissues.

The majority of human cancers (80–90 %) are of epithelial origin. Loss of E-cadherin expression...

Keywords

Adenomatous Polyposis Coli Invasion Pattern Diffuse Gastric Cancer Hereditary Diffuse Gastric Cancer Classical Cadherins 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Benign Tumor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 381. doi:10.1007/978-3-642-16483-5_579Google Scholar
  2. (2012) Beta-Catenin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 385. doi:10.1007/978-3-642-16483-5_889Google Scholar
  3. (2012) Epithelial Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1291–1292. doi:10.1007/978-3-642-16483-5_1958Google Scholar
  4. (2012) Germline Mutation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1544. doi:10.1007/978-3-642-16483-5_2404Google Scholar
  5. (2012) Growth Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1607–1608. doi:10.1007/978-3-642-16483-5_2520Google Scholar
  6. (2012) Hypermethylation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1784. doi:10.1007/978-3-642-16483-5_2910Google Scholar
  7. (2012) Malignant Tumor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2150. doi:10.1007/978-3-642-16483-5_3519Google Scholar
  8. (2012) Renal Cancer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3225–3226. doi:10.1007/978-3-642-16483-5_6575Google Scholar
  9. (2012) Transcription Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi:10.1007/978-3-642-16483-5_5901Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Clinical-Biological Sciences, Centre of BiomedicineInstitute of Biochemistry and Genetics, University of BaselBaselSwitzerland