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Encyclopedia of Cancer pp 1–2Cite as

Duffy Antigen Receptor for Chemokines

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Synonyms

DARC; gp-Fy

Definition

DARC or Duffy antigen receptor for chemokines is a seven-transmembrane protein, which has a molecular weight of ∼45 k Da. DARC is expressed on vascular endothelium (plasma membrane and caveolae) as well as on red blood cells. It binds to chemokines of both C–C and C–X–C motif chemokines, but signal transduction through the G-protein-coupled receptor or Ca2+ flux is not observed. The genomic organization of the DARC gene consists of two alleles Fya and Fyb that are associated with a polymorphism at the 44-amino acid residue.

Characteristics

DARC is a receptor for malaria parasite Plasmodium vivax, and 70 % of the West African population that lack DARC expression on their erythrocytes are resistant to malaria infection. A novel function of DARC has been identified where it has been found to interact with the metastasis suppressor KAI1CD82. When cancer cells expressing KAI1 intravasate and come in contact with the endothelial lining of small blood vessels...

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References

  • Bandyopadhyay S et al (2006) Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med 12(8):933–938

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  • Iiizumi M, Bandyopadhyay S, Watabe K (2007) Interaction of Duffy antigen receptor for chemokines and KAI1: a critical step in metastasis suppression. Cancer Res 67(4):1411–1414

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  • Iwamoto S et al (1995) Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. Blood 85(3):622–626

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  • Mashimo T et al (2000) Activation of the tumor metastasis suppressor gene, KAI1, by etoposide is mediated by p53 and c-Jun genes. Biochem Biophys Res Commun 274(2):370–376

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  • Miller LH et al (1975) Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science 189(4202):561–563

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Author information

Authors and Affiliations

  1. School of Medicine, Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, Springfield, IL, USA

    Sonia Mohinta

  2. School of Medicine, Department of Cancer Biology, Wake Forest University, Winston Salem, NC, USA

    Kounosuke Watabe

Authors
  1. Sonia Mohinta
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  2. Kounosuke Watabe
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Corresponding author

Correspondence to Sonia Mohinta .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Mohinta, S., Watabe, K. (2015). Duffy Antigen Receptor for Chemokines. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1750-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1750-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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