Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Duffy Antigen Receptor for Chemokines

  • Sonia Mohinta
  • Kounosuke Watabe
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1750-2



DARC or Duffy antigen receptor for chemokines is a seven-transmembrane protein, which has a molecular weight of ∼45 k Da. DARC is expressed on vascular endothelium (plasma membrane and caveolae) as well as on red blood cells. It binds to chemokines of both C–C and C–X–C motif chemokines, but signal transduction through the G-protein-coupled receptor or Ca2+ flux is not observed. The genomic organization of the DARC gene consists of two alleles Fya and Fyb that are associated with a polymorphism at the 44-amino acid residue.


DARC is a receptor for malaria parasite Plasmodium vivax, and 70 % of the West African population that lack DARC expression on their erythrocytes are resistant to malaria infection. A novel function of DARC has been identified where it has been found to interact with the metastasis suppressor KAI1CD82. When cancer cells expressing KAI1 intravasate and come in contact with the endothelial lining of small blood vessels...


Breast Cancer Malaria Parasite Cellular Senescence Antigen Receptor Metastasis Suppressor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.School of Medicine, Department of Medical Microbiology, Immunology and Cell BiologySouthern Illinois UniversitySpringfieldUSA
  2. 2.School of Medicine, Department of Cancer BiologyWake Forest UniversityWinston SalemUSA