Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Duffy Antigen Receptor for Chemokines

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1750-2

Synonyms

Definition

DARC or Duffy antigen receptor for chemokines is a seven-transmembrane protein, which has a molecular weight of ∼45 k Da. DARC is expressed on vascular endothelium (plasma membrane and caveolae) as well as on red blood cells. It binds to chemokines of both C–C and C–X–C motif chemokines, but signal transduction through the G-protein-coupled receptor or Ca2+ flux is not observed. The genomic organization of the DARC gene consists of two alleles Fya and Fyb that are associated with a polymorphism at the 44-amino acid residue.

Characteristics

DARC is a receptor for malaria parasite Plasmodium vivax, and 70 % of the West African population that lack DARC expression on their erythrocytes are resistant to malaria infection. A novel function of DARC has been identified where it has been found to interact with the metastasis suppressor KAI1CD82. When cancer cells expressing KAI1 intravasate and come in contact with the endothelial lining of small blood vessels...

Keywords

Breast Cancer Malaria Parasite Cellular Senescence Antigen Receptor Metastasis Suppressor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bandyopadhyay S et al (2006) Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med 12(8):933–938CrossRefPubMedGoogle Scholar
  2. Iiizumi M, Bandyopadhyay S, Watabe K (2007) Interaction of Duffy antigen receptor for chemokines and KAI1: a critical step in metastasis suppression. Cancer Res 67(4):1411–1414CrossRefPubMedGoogle Scholar
  3. Iwamoto S et al (1995) Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. Blood 85(3):622–626PubMedGoogle Scholar
  4. Mashimo T et al (2000) Activation of the tumor metastasis suppressor gene, KAI1, by etoposide is mediated by p53 and c-Jun genes. Biochem Biophys Res Commun 274(2):370–376CrossRefPubMedGoogle Scholar
  5. Miller LH et al (1975) Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science 189(4202):561–563CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.School of Medicine, Department of Medical Microbiology, Immunology and Cell BiologySouthern Illinois UniversitySpringfieldUSA
  2. 2.School of Medicine, Department of Cancer BiologyWake Forest UniversityWinston SalemUSA