Ductal Carcinoma In Situ
Ductal carcinoma in situ (DCIS) is a preinvasive breast cancer. The malignant cells remain confined behind an intact basement membrane. The tumor can spread locally along the breast ducts (up to 20 or so) that form the breast, but DCIS does not possess the ability to invade into surrounding structures or spread to distant sites. If left, over time, a proportion of cases will develop into an invasive breast cancer, which does have the ability to spread and metastasize.
Over 90 % of DCIS that is diagnosed cannot be felt on breast examination and is completely asymptomatic; it is often only detected at screening mammograms. Approximately 70 % of these mammographically detected cases present as microcalcifications. Atypical mammographic features include circumscribed nodules, ill-defined masses, duct asymmetry, and architectural distortion....
KeywordsNipple Discharge Individual Patient Basis Bloody Nipple Discharge Deep Inferior Epigastric Perforator Suspicious Microcalcifications
- Silverstein M (2002) Ductal carcinoma in situ of the breast, 2nd edn. Lippincott Williams and Wilkins, Philadelphia. ISBN 0-781732-23-9Google Scholar
- The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. The management of Ductal Carcinoma in Situ (DCIS) (1998) Can Med Assoc J 158(Suppl):S27–S34Google Scholar