Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ductal Carcinoma In Situ

  • Nicola L. P. Barnes
  • Nigel J. Bundred
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1748-2



Ductal carcinoma in situ (DCIS) is a preinvasive breast cancer. The malignant cells remain confined behind an intact basement membrane. The tumor can spread locally along the breast ducts (up to 20 or so) that form the breast, but DCIS does not possess the ability to invade into surrounding structures or spread to distant sites. If left, over time, a proportion of cases will develop into an invasive breast cancer, which does have the ability to spread and metastasize.



Over 90 % of DCIS that is diagnosed cannot be felt on breast examination and is completely asymptomatic; it is often only detected at screening mammograms. Approximately 70 % of these mammographically detected cases present as microcalcifications. Atypical mammographic features include circumscribed nodules, ill-defined masses, duct asymmetry, and architectural distortion....


Nipple Discharge Individual Patient Basis Bloody Nipple Discharge Deep Inferior Epigastric Perforator Suspicious Microcalcifications 
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  1. Ernster VL, Barclay J (1997) Increases in ductal carcinoma in situ (DCIS) of the breast in relation to mammography: a dilemma. J Natl Cancer Inst Monogr 22:151–156PubMedGoogle Scholar
  2. Schwartz GF, Solin LJ, Olivotto IA et al (2000) The consensus conference on the treatment of in situ ductal carcinoma of the breast, 22–25 April 1999. Cancer 88(4):946–954CrossRefPubMedGoogle Scholar
  3. Silverstein M (2002) Ductal carcinoma in situ of the breast, 2nd edn. Lippincott Williams and Wilkins, Philadelphia. ISBN 0-781732-23-9Google Scholar
  4. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. The management of Ductal Carcinoma in Situ (DCIS) (1998) Can Med Assoc J 158(Suppl):S27–S34Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Academic SurgerySouth Manchester University HospitalManchesterUK