Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Aldehyde Dehydrogenases

  • Jan S. Moreb
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_173-7

Synonyms

Definition

A group of NAD(P)+-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding acids. Nineteen forms exist in humans and they are present in all tissues. Aldehydes are abundant in nature and can be generated during normal metabolism or from metabolism of exogenous drugs and environmental substrates. Several of these enzymes are important in detoxification of anticancer drugs.

Chracteristics

Aldehyde dehydrogenase (ALDH) isoenzymes are found in all cell types and play an essential role in the removal of toxic aldehydes as well as the production of active molecules. Aldehydes are abundant in nature and come from normal endogenous metabolism or from ingested materials or environmental sources. Examples include the removal of aldehydes produced from alcohol ingestion and toxic aldehdyes from smoke. Some ALDH isoenzymes are involved in the synthesis of retinoic acid (from Vitamin A) and purines as well as the metabolism of corticosteroids and...

Keywords

Retinoic Acid Acute Promyelocytic Leukemia ALDH Activity Succinic Semialdehyde ALDH Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  4. Moreb JS (2008) Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther 3:237–246CrossRefPubMedGoogle Scholar
  5. Moreb JS, Gabr A, Vartikar GR, Gowda S, Zucali JR, Mohuczy D (2005) Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde. J Pharmacol Exp Ther 312:339–345CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Immunodeficient NUDE MICE. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1816. doi: 10.1007/978-3-642-16483-5_2986Google Scholar
  2. (2012) Neurotransmitters. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2505. doi: 10.1007/978-3-642-16483-5_4049Google Scholar
  3. Johnson BA (2015) Disulfiram. In: Stolerman IP, Price LH (ed) Encyclopedia of psychopharmacology. Springer, Berlin/Heidelberg, pp 531–534. doi: 10.1007/978-3-642-36172-2_172Google Scholar
  4. http://ghr.nlm.nih.gov/condition/hyperprolinemiaGoogle Scholar
  5. http://ghr.nlm.nih.gov/condition/pyridoxine-dependent-epilepsyGoogle Scholar
  6. http://ghr.nlm.nih.gov/condition/sjogren-larsson-syndromeGoogle Scholar
  7. http://ghr.nlm.nih.gov/condition/succinic-semialdehyde-dehydrogenase-deficiencyGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Medicine, Division of Hematology/OncologyCollege of Medicine, University of FloridaGainesvilleUSA