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Encyclopedia of Cancer pp 1–4Cite as

Doublecortin

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Synonyms

DCX; Doublecortex; Doublecortin

Definition

Doublecortex (DCX) is a brain-specific gene, deficient in glioma tumor cells and suppresses tumor in brain. DCX is a substrate of Jun N-terminal Kinase (JNK) and highly phosphorylated by JNK. The phosphorylated DCX interacts with a potent tumor suppressor, spinophilin neurabin II, and then associates with the protein serine/threonine phosphatase, protein phosphatase-1 (PP1). This association of protein complex of DCX, neurabin II, and PP1 leads to inhibition of anchorage-independent growth of glioma tumor cells and eventually suppresses tumor development.

Characteristics

DCX is a microtubule-associated protein(MAP), which directly interacts with microtubules (MTs) without any additional mediators. This interaction results in stabilization and bundling of MTs both in vivo and in vitro. DCX is a basic protein with an isoelectric point of 10, typical of other MT-binding proteins. DCX is an evolutionarily conserved MT binding protein...

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References

  • Demuth T, Berens ME (2004) Molecular mechanisms of glioma cell migration and invasion. J Neurooncol 70(2):217–228 (Review)

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  • Furnari FB, Lin H, Huang HS et al (1997) Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A 94:12479–12484

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  • Santra M, Zhang X, Santra S et al (2006a) Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells. Cancer Res 66(24):11726–11735

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  • Santra M, Lui XS, Zhang J et al (2006b) Ectopic expression of doublecortin protects adult mouse progenitor cells and human glioma cells from severe oxygen and glucose deprivation. Neuroscience 92:7016–7020

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Author information

Authors and Affiliations

  1. Neurology Research, Henry Ford Health System, Detroit, MI, USA

    Manoranjan Santra & Michael Chopp

Authors
  1. Manoranjan Santra
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  2. Michael Chopp
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Corresponding author

Correspondence to Manoranjan Santra .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Santra, M., Chopp, M. (2015). Doublecortin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1720-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1720-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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