Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Manoranjan Santra
  • Michael Chopp
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1720-2



Doublecortex (DCX) is a brain-specific gene, deficient in glioma tumor cells and suppresses tumor in brain. DCX is a substrate of Jun N-terminal Kinase (JNK) and highly phosphorylated by JNK. The phosphorylated DCX interacts with a potent tumor suppressor, spinophilin neurabin II, and then associates with the protein serine/threonine phosphatase, protein phosphatase-1 (PP1). This association of protein complex of DCX, neurabin II, and PP1 leads to inhibition of anchorage-independent growth of glioma tumor cells and eventually suppresses tumor development.


DCX is a microtubule-associated protein(MAP), which directly interacts with microtubules (MTs) without any additional mediators. This interaction results in stabilization and bundling of MTs both in vivo and in vitro. DCX is a basic protein with an isoelectric point of 10, typical of other MT-binding proteins. DCX is an evolutionarily conserved MT binding protein...


Glioma Cell Okadaic Acid Dynamic Instability Cell Adhesion Protein Common Genetic Alteration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Neurology ResearchHenry Ford Health SystemDetroitUSA