Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Doublecortin

  • Manoranjan Santra
  • Michael Chopp
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1720-2

Synonyms

Definition

Doublecortex (DCX) is a brain-specific gene, deficient in glioma tumor cells and suppresses tumor in brain. DCX is a substrate of Jun N-terminal Kinase (JNK) and highly phosphorylated by JNK. The phosphorylated DCX interacts with a potent tumor suppressor, spinophilin neurabin II, and then associates with the protein serine/threonine phosphatase, protein phosphatase-1 (PP1). This association of protein complex of DCX, neurabin II, and PP1 leads to inhibition of anchorage-independent growth of glioma tumor cells and eventually suppresses tumor development.

Characteristics

DCX is a microtubule-associated protein(MAP), which directly interacts with microtubules (MTs) without any additional mediators. This interaction results in stabilization and bundling of MTs both in vivo and in vitro. DCX is a basic protein with an isoelectric point of 10, typical of other MT-binding proteins. DCX is an evolutionarily conserved MT binding protein...

Keywords

Glioma Cell Okadaic Acid Dynamic Instability Cell Adhesion Protein Common Genetic Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  4. Santra M, Zhang X, Santra S et al (2006a) Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells. Cancer Res 66(24):11726–11735CrossRefPubMedGoogle Scholar
  5. Santra M, Lui XS, Zhang J et al (2006b) Ectopic expression of doublecortin protects adult mouse progenitor cells and human glioma cells from severe oxygen and glucose deprivation. Neuroscience 92:7016–7020Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Neurology ResearchHenry Ford Health SystemDetroitUSA