Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Alcohol Consumption

  • Helmut K. Seitz
  • Sebastian Mueller
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_168-2

Definition

Alcohol is a widely used stimulant, toxin and nutrient, depending on doses and drinking pattern. Its chronic abuse damages almost all cells in the human body and results in organ injury, including the development of certain cancers.

Characteristics

Alcohol is responsible for 390,000 cancer cases worldwide, representing 3.6 % of all cancers (5.2 % in men and 1.7 % in women). In February 2007, the International Agency for Research on Cancer (IARC) invited 26 scientists from 15 countries to evaluate the evidence for ethanol and ethanol-containing beverages as a cancer causing agent. The experts reviewed all epidemiological and experimental studies covering this topic and came finally to the following conclusion:

“Regular alcohol consumption is associated with an increased risk for cancer of the oral cavity, pharynx, larynx, esophagus, liver, breast and colorectum. There is substantial mechanistic evidence in humans deficient in aldehyde dehydrogenase that acetaldehyde derived...

Keywords

Retinoic Acid Gastroesophageal Reflux Disease Increase Breast Cancer Risk Ethanol Oxidation Increase Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Baan R, Straif K, Grosse Y et al (2007) WHO International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of alcoholic beverages. Lancet Oncol 8:292–293PubMedCrossRefGoogle Scholar
  2. Bofetta P, Hashibe M (2006) Alcohol and cancer. Lancet Oncol 7:149–156CrossRefGoogle Scholar
  3. Pöschl G, Seitz HK (2004) Alcohol and cancer. Alcohol Alcohol 39:155–165PubMedCrossRefGoogle Scholar
  4. Seitz HK, Stickel F (2007) Molecular mechanisms in alcohol mediated carcinogenesis. Nat Rev Cancer 7:599–612PubMedCrossRefGoogle Scholar
  5. Yokoyama A, Muramatsu T, Ohmori T et al (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19:1383–1387PubMedCrossRefGoogle Scholar

See Also

  1. (2012) Acetaldehyde. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 16. doi:10.1007/978-3-642-16483-5_22Google Scholar
  2. (2012) Acetaldehydehydrogenase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 16. doi:10.1007/978-3-642-16483-5_23Google Scholar
  3. (2012) Alcohol dehydrogenase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 120. doi:10.1007/978-3-642-16483-5_6732Google Scholar
  4. (2012) Alcohol-mediated cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 126. doi:10.1007/978-3-642-16483-5_170Google Scholar
  5. (2012) Chronic liver disease. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 849. doi:10.1007/978-3-642-16483-5_1152Google Scholar
  6. (2012) Cirrhosis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 869. doi:10.1007/978-3-642-16483-5_1184Google Scholar
  7. (2012) Colorectal cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 916. doi:10.1007/978-3-642-16483-5_1265Google Scholar
  8. (2012) Estrogens. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1333. doi:10.1007/978-3-642-16483-5_2019Google Scholar
  9. (2012) Gastroesophageal reflux disease. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1511. doi:10.1007/978-3-642-16483-5_2334Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Centre of Alcohol Research (CAR)University of HeidelbergHeidelbergGermany
  2. 2.Department of MedicineSalem Medical CenterHeidelbergGermany