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DLC1

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 59 Accesses

Synonyms

ARHGAP7; Deleted in liver cancer 1; Rho-GTPase-activating protein 7; STARD12; START domain-containing protein

Definition

DLC1 is a tumor suppressor gene frequently underexpressed in various types of cancers. Genomic deletion and promoter hypermethylation may account for the inactivation of DLC1 in human cancers. Functionally, overexpression of DLC1 can result in the tumor suppression in cancer cells and regulation of cytoskeleton organization.

Characteristics

Deleted in liver cancer 1 (DLC1), also known as Rho- GTPase -activating protein 7 (ARHGAP7) and START domain-containing protein (STARD12), is a putative tumor suppressor gene identified from primary hepatocellular carcinoma (HCC) in 1998. Human DLC1 gene was mapped to chromosome region 8p21.3–22. The full-length DLC1 mRNA is 6 kb long and consists of 14 exons which encode a protein of 1,091 amino acids. In silico analysis indicated that DLC1 shares 86 % sequence homology with rat p122 RhoGAPand is likely to be its human...

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References

  • Ng IOL, Liang ZD, Cao L et al (2000) DLC1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC1. Cancer Res 60:6581–6584

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  • Wong CM, Lee JMF, Ching YP et al (2003) Genetic and epigenetic alterations of DLC1 gene in hepatocellular carcinoma. Cancer Res 63:7646–7651

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  • Wong CM, Yam JWP, Ching YP et al (2005) Rho GTPase activating protein DLC1 (deleted in liver cancer) suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res 65:8861–8868

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  • Yam JWP, Ko FCF, Chan CY et al (2006) Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression. Cancer Res 66:8367–8372

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  • Yuan BZ, Miller MJ, Keck CL et al (1998) Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC1) homologous to rat RhoGAP. Cancer Res 58:2196–2199

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See Also

  • (2012) Actin cytoskeleton. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 19. doi:10.1007/978-3-642-16483-5_43

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  • (2012) Caveolae. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 682. doi:10.1007/978-3-642-16483-5_894

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  • (2012) DNA methylation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1140. doi:10.1007/978-3-642-16483-5_1682

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  • (2012) Homozygous deletion. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1729. doi:10.1007/978-3-642-16483-5_2807

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  • (2012) Knock-out mouse. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1957. doi:10.1007/978-3-642-16483-5_3239

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  • (2012) Loss of heterozygosity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2075-2076. doi:10.1007/978-3-642-16483-5_3415

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  • (2012) Nude mice. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2584. doi:10.1007/978-3-642-16483-5_4172

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  • (2012) Promoter. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3004. doi:10.1007/978-3-642-16483-5_4768

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  • (2012) Promoter hypermethylation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3004. doi:10.1007/978-3-642-16483-5_4769

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  • (2012) Single nucleotide polymorphism. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3412. doi:10.1007/978-3-642-16483-5_5316

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  • (2012) Tensin2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3647. doi:10.1007/978-3-642-16483-5_5726

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Author information

Authors and Affiliations

  1. Department of Pathology, The University of Hong Kong, Hong Kong, China

    Judy W. P. Yam, Chun-Ming Wong & Irene O. L. Ng

Authors
  1. Judy W. P. Yam
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  2. Chun-Ming Wong
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  3. Irene O. L. Ng
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Corresponding author

Correspondence to Judy W. P. Yam .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Yam, J.W.P., Wong, CM., Ng, I.O.L. (2014). DLC1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1656-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1656-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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